CAS 113852-37-2: Cidofovir

Description: Cidofovir is an antiviral medication primarily used in the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It is a nucleotide analogue of cytosine, which inhibits viral DNA polymerase, thereby preventing viral replication. Cidofovir is characterized by its high potency against a range of DNA viruses, including herpesviruses. The compound is typically administered intravenously due to its poor oral bioavailability. It has a relatively long half-life, allowing for less frequent dosing compared to other antiviral agents. Cidofovir is known to have nephrotoxic effects, necessitating careful monitoring of renal function during treatment. Additionally, it is often co-administered with probenecid to mitigate nephrotoxicity by reducing renal tubular secretion. The substance is classified as a prescription medication and is not recommended for use in pregnant women due to potential teratogenic effects. Overall, Cidofovir represents a critical therapeutic option for managing severe viral infections in immunocompromised patients.

Formula: C₈H₁₄N₃O₆P

InChI: InChI=1S/C8H14N3O6P/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16)/t6-/m0/s1

InChI key: InChIKey=VWFCHDSQECPREK-LURJTMIESA-N

SMILES: O=C1N=C(N)C=CN1CC(OCP(=O)(O)O)CO

Synonyms:

• (S)-1-(3-Hydroxy-2-phosphonomethoxypropyl)cytosine
• (S)-Hpmpc
• ({[(2S)-1-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-hydroxypropan-2-yl]oxy}methyl)phosphonic acid
• 1-(S)-(3-Hydroxy-2-phosphonylmethoxypropyl)cytosine
• 1-[(S)-3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine
• Cidofovir (anhydrous)
• Cidofovir monophosphate
• Cidovir
• Gs 0504
• Hpmpc
• P-[[(1S)-2-(4-Amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]phosphonic acid
• Phosphonic acid, ((2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy)methyl)-, (S)-
• Phosphonic acid, P-[[(1S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]-
• Phosphonic acid, [[(1S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]-
• Unii-768M1V522C
• Vistide
• {[2-(4-amino-2-oxopyrimidin-1(2H)-yl)-1-(hydroxymethyl)ethoxy]methyl}phosphonic acid

[1-(4-Amino-2-oxo-pyrimidin-1-yl)-3-hydroxy-propan-2-yl]oxymethylphosphonic acid

CAS: 113852-37-2

• Formula: C₈H₁₄N₃O₆P
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 279.187

Cidofovir, anhydrous

CAS: 113852-37-2

• Formula: C₈H₁₄N₃O₆P
• Molecular weight: 297.20

Cidofovir

CAS: 113852-37-2

• Purity: 99.76%
• Molecular weight: 279.19g/mol

Cidofovir

CAS: 113852-37-2

• Purity: 98%
• Molecular weight: 279.19g/mol

Cidofovir hydrate

CAS: 113852-37-2

• Formula: C₈H₁₄N₃O₆P·xH₂O
• Purity: 98.0 - 102.0 % (dried basis)
• Color and Shape: White or off-white crystalline powder
• Molecular weight: 279.19 (anhydrous)

Cidofovir

CAS: 113852-37-2

• Formula: C₈H₁₄N₃O₆P
• Color and Shape: Neat
• Molecular weight: 279.19

Cidofovir

CAS: 113852-37-2

• Formula: C₈H₁₄N₃O₆P
• Color and Shape: Neat
• Molecular weight: 279.19

Cidofovir

CAS: 113852-37-2

Cidofovir ((S)-HPMPC) 通过特异性抑制病毒 DNA 合成来抑制病毒复制。

• Formula: C₈H₁₄N₃O₆P
• Purity: 99.24% - 99.76%
• Color and Shape: Fluffy White Powder
• Molecular weight: 279.19

Cidofovir Hydrate

CAS: 113852-37-2

Applications An injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with …

• Formula: C₈H₁₄N₃O₆P
• Color and Shape: White Powder
• Molecular weight: 279.19

Cidofovir anhydrous - Bio-X ™

CAS: 113852-37-2

Cidofovir is an anti-viral agent that is used to treat Cytomegalovirus (CMV) retinitis in patients …

• Formula: C₈H₁₄N₃O₆P
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 279.19 g/mol

Cidofovir (anhydrous)

CAS: 113852-37-2

Anti-viral; DNA polymerase inhibitor

• Formula: C₈H₁₄N₃O₆P
• Purity: Min. 95%
• Color and Shape: White Powder
• Molecular weight: 279.19 g/mol