CAS 113852-37-2

Cidofovir

Description:

Cidofovir is an antiviral medication primarily used in the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It is a nucleotide analogue of cytosine, which inhibits viral DNA polymerase, thereby preventing viral replication. Cidofovir is characterized by its high potency against a range of DNA viruses, including herpesviruses. The compound is typically administered intravenously due to its poor oral bioavailability. It has a relatively long half-life, allowing for less frequent dosing compared to other antiviral agents. Cidofovir is known to have nephrotoxic effects, necessitating careful monitoring of renal function during treatment. Additionally, it is often co-administered with probenecid to mitigate nephrotoxicity by reducing renal tubular secretion. The substance is classified as a prescription medication and is not recommended for use in pregnant women due to potential teratogenic effects. Overall, Cidofovir represents a critical therapeutic option for managing severe viral infections in immunocompromised patients.

Formula: C₈H₁₄N₃O₆P

InChI: InChI=1/C8H14N3O6P/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16)

InChI key: InChIKey=VWFCHDSQECPREK-LURJTMIESA-N

SMILES: C([C@H](OCP(=O)(O)O)CO)N1C(=O)N=C(N)C=C1

Synonyms:

• (S)-1-(3-Hydroxy-2-phosphonomethoxypropyl)cytosine
• (S)-Hpmpc
• ({[(2S)-1-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-hydroxypropan-2-yl]oxy}methyl)phosphonic acid
• 1-(S)-(3-Hydroxy-2-phosphonylmethoxypropyl)cytosine
• 1-[(S)-3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine
• Cidofovir (anhydrous)
• Cidofovir monophosphate
• Cidovir
• Gs 0504
• Hpmpc
• P-[[(1S)-2-(4-Amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]phosphonic acid
• Phosphonic acid, ((2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy)methyl)-, (S)-
• Phosphonic acid, P-[[(1S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]-
• Phosphonic acid, [[(1S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]-
• Unii-768M1V522C
• Vistide
• {[2-(4-amino-2-oxopyrimidin-1(2H)-yl)-1-(hydroxymethyl)ethoxy]methyl}phosphonic acid
• (S)-1-[3-HYDROXY-2-(PHOSPHONYL-METHOXY)PROPYL]-CYTOSINE
• (S)-1-(3-HYDROXY-2-PHOSPHONYLMETHOXYPROYPL)CYTOSINE
• GS-504
• [[(S)-2-[(4-Amino-2-oxo-1,2-dihydropyrimidin)-1-yl]-1-(hydroxymethyl)ethoxy]methyl]phosphonic acid
• [1-(4-amino-2-oxo-pyrimidin-1-yl)-3-hydroxy-propan-2-yl]oxymethylphosphonic acid
• CIDOFOVIR
• CIDOFOVIR, S)-1-(3-HYDROXY-2-PHOSPHONYLMETHOXYPROYPL)CYTOSINE
• (S)-[[2-(4-Amino-2-oxo-1(2H)pyrimidinyl)-l-(hydroxymethyl)ethoxy]methyl]phosphonic acid
• 1-[(2S)-3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine

[1-(4-Amino-2-oxo-pyrimidin-1-yl)-3-hydroxy-propan-2-yl]oxymethylphosphonic acid

CAS: 113852-37-2

Formula: C₈H₁₄N₃O₆P

Purity: 98%

Color and Shape: Solid

Molecular weight: 279.1870

Ref: IN-DA00393G

Cidofovir, anhydrous

CAS: 113852-37-2

Formula: C₈H₁₄N₃O₆P

Molecular weight: 297.20

Ref: 7W-GP4917

Cidofovir

CAS: 113852-37-2

Cidofovir

Purity: ≥98%

Molecular weight: 279.19g/mol

Ref: 54-BUP10119

Cidofovir

CAS: 113852-37-2

Cidofovir

Purity: 98%

Molecular weight: 279.19g/mol

Ref: 54-OR1026524

Cidofovir hydrate

CAS: 113852-37-2

Formula: C₈H₁₄N₃O₆P·xH₂O

Purity: 98.0 - 102.0 % (dried basis)

Color and Shape: White or off-white crystalline powder

Molecular weight: 279.19 (anhydrous)

Ref: 7W-GP0753

Cidofovir

CAS: 113852-37-2

Formula: C₈H₁₄N₃O₆P

Color and Shape: Neat

Molecular weight: 279.19

Ref: 04-C11666335

Cidofovir

Controlled Product

CAS: 113852-37-2

Formula: C₈H₁₄N₃O₆P

Color and Shape: Neat

Molecular weight: 279.19

Ref: 86-MM3558.00

Cidofovir

CAS: 113852-37-2

Cidofovir ((S)-HPMPC) 通过特异性抑制病毒 DNA 合成来抑制病毒复制。

Formula: C₈H₁₄N₃O₆P

Purity: 99.24% - 99.76%

Color and Shape: Fluffy White Powder

Molecular weight: 279.19

Ref: TM-T6244

Cidofovir Hydrate

CAS: 113852-37-2

Applications An injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It suppresses CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription. It is used in the treatment of acyclovir resistant herpes as well as a complementary intralesional therapy against papillomatosis caused by human papillomavirus (HPV).
References Rahal, F.M. et al.: Ann. Internal Med., 125, 98 (1996); Johnson, J.A. et al.: Antimicrob. Agents Chemother., 43, 1190 (1999); Ho, H.T. et al.: Mol. Pharmacol., 41, 197 (1992);

Formula: C₈H₁₄N₃O₆P

Color and Shape: White Powder

Molecular weight: 279.19

Ref: TR-C433500

Cidofovir anhydrous - Bio-X ™

CAS: 113852-37-2

Cidofovir is an anti-viral agent that is used to treat Cytomegalovirus (CMV) retinitis in patients with AIDS. This drug suppresses CMV replication by inhibiting viral DNA synthesis.

Formula: C₈H₁₄N₃O₆P

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 279.19 g/mol

Ref: 3D-BC164304

Cidofovir (anhydrous)

CAS: 113852-37-2

Anti-viral; DNA polymerase inhibitor

Formula: C₈H₁₄N₃O₆P

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 279.19 g/mol

Ref: 3D-FC46273