CAS 1138549-36-6

CX-5461

Description:

CX-5461 is a small molecule that primarily functions as a selective inhibitor of RNA polymerase I, which is crucial for ribosomal RNA synthesis. This compound has garnered attention in cancer research due to its potential to induce nucleolar stress and selectively target cancer cells, particularly those with specific genetic backgrounds, such as those with mutations in the p53 tumor suppressor gene. CX-5461 has shown promise in preclinical studies for its ability to inhibit tumor growth and enhance the efficacy of other therapeutic agents. In terms of its chemical characteristics, CX-5461 is classified as a heterocyclic compound, featuring a unique structure that contributes to its biological activity. Its mechanism of action involves the disruption of ribosomal biogenesis, leading to apoptosis in cancer cells. Ongoing research is focused on understanding its pharmacokinetics, optimal dosing strategies, and potential combination therapies to maximize its therapeutic effects while minimizing side effects. Overall, CX-5461 represents a novel approach in the field of targeted cancer therapy.

CX-5461

CAS: 1138549-36-6

Formula: C₂₇H₂₇N₇O₂S

Purity: 98%

Color and Shape: Solid

Molecular weight: 513.6140

Ref: IN-DA008TF4

2-(4-Methyl-1,4-Diazepan-1-Yl)-N-((5-Methylpyrazin-2-Yl)Methyl)-5-Oxo-5H-Benzo[4,5]Thiazolo[3,2-A][1,8]Naphthyridine-6-Carboxamide

CAS: 1138549-36-6

2-(4-Methyl-1,4-Diazepan-1-Yl)-N-((5-Methylpyrazin-2-Yl)Methyl)-5-Oxo-5H-Benzo[4,5]Thiazolo[3,2-A][1,8]Naphthyridine-6-Carboxamide

Purity: 98%

Molecular weight: 513.61g/mol

Ref: 54-OR1024369

CX-5461

CAS: 1138549-36-6

CX-5461

Purity: ≥95%

Molecular weight: 513.61g/mol

Ref: 54-BUP02331

CX-5461

CAS: 1138549-36-6

CX5461 is an orally rRNA synthesis inhibitor that inhibits Pol I-driven rRNA transcription. CX5461 has antitumor activity. Cost-effective and quality-assured.

Formula: C₂₇H₂₇N₇O₂S

Purity: 95.44% - 99.25%

Color and Shape: Solid

Molecular weight: 513.61

Ref: TM-T2100

CX 5461

CAS: 1138549-36-6

CX 5461 is a potent, selective inhibitor of the transcription elongation factor, polymerase (PEP). It binds to the PEP-DNA template complex and blocks dNTP incorporation into RNA. Studies in vitro show that CX 5461 inhibits cancer cell proliferation and induces autophagy and apoptosis. The drug also has genotoxic activity in vitro, as it inhibits DNA synthesis by inhibiting ribosome synthesis. CX 5461 has been shown to be effective against endometriosis in vivo as well as myeloma cells in vitro.

Purity: Min. 95%

Ref: 3D-BC168026