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CAS 113873-67-9

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calcineurin substrate

Description:
Calcineurin substrate, identified by the CAS number 113873-67-9, is a peptide that serves as a substrate for the enzyme calcineurin, which is a calcium/calmodulin-dependent serine/threonine phosphatase. This substrate is characterized by its specific amino acid sequence that allows it to be recognized and dephosphorylated by calcineurin. The activity of calcineurin is crucial in various cellular processes, including T-cell activation and neuronal signaling, making its substrates important in immunology and neurobiology. The interaction between calcineurin and its substrate is regulated by calcium ions, which influence the enzyme's activity. Additionally, the phosphorylation state of the substrate can affect its interaction with calcineurin, highlighting the dynamic nature of this biochemical relationship. Overall, calcineurin substrates play a significant role in signal transduction pathways, and their study is essential for understanding various physiological and pathological processes.
Formula:C92H150N28O29
Synonyms:
  • H-Asp-Leu-Asp-Val-Pro-Ile-Pro-Gly-Arg-Phe-Asp-Arg-Arg-Val-Ser-Val-Ala-Ala-Glu-OH
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