CAS 113886-71-8

N4-Acetyl-2′-O-methylcytidine

Description:

N4-Acetyl-2′-O-methylcytidine is a modified nucleoside that features an acetyl group at the N4 position of the cytidine base and a methoxy group at the 2′ position of the ribose sugar. This compound is characterized by its structural modifications that enhance its stability and bioavailability compared to unmodified nucleosides. The acetyl group can influence the nucleoside's interaction with enzymes and its incorporation into RNA, potentially affecting its biological activity. The 2′-O-methyl modification is known to confer resistance to ribonucleases, making it a valuable component in therapeutic applications, particularly in the development of RNA-based drugs and vaccines. N4-Acetyl-2′-O-methylcytidine is often studied in the context of RNA synthesis and modification, as well as in the design of oligonucleotides for research and therapeutic purposes. Its unique properties make it a subject of interest in molecular biology and medicinal chemistry, where it may play a role in enhancing the efficacy of RNA therapeutics.

Formula: C₁₂H₁₇N₃O₆

InChI: InChI=1S/C12H17N3O6/c1-6(17)13-8-3-4-15(12(19)14-8)11-10(20-2)9(18)7(5-16)21-11/h3-4,7,9-11,16,18H,5H2,1-2H3,(H,13,14,17,19)/t7-,9-,10-,11-/m1/s1

InChI key: InChIKey=CYDFBLGNJUNSCC-QCNRFFRDSA-N

SMILES: O(C)[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)N=C(NC(C)=O)C=C2

Synonyms:

• N-Acetyl-2'-O-methylcytidine
• N4-Acetyl-2'-O-Methyl-cytidine
• N4-Acetyl-2'-O-methylcytidine
• N⁴-Acetyl-2′-O-methylcytidine
• Cytidine, N-acetyl-2′-O-methyl-
• N4-Ac-2'-OMe-rC
• N-(1-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide
• N4-Ac-2'-OMe-C
• Ac-2'-OMe-C
• N4-Acetyl-2’-OMe-Cytidine
• N4-Ac-2'-O-Me-Cr

Cytidine, N-acetyl-2'-O-methyl-

CAS: 113886-71-8

Formula: C₁₂H₁₇N₃O₆

Purity: 97%

Color and Shape: Solid

Molecular weight: 299.2799

Ref: IN-DA0009ZI

N4-Acetyl-2'-O-methylcytidine

CAS: 113886-71-8

N4-Acetyl-2'-O-methylcytidine

Purity: 97%

Molecular weight: 299.28g/mol

Ref: 54-OR1034711

N4-Acetyl-2''-O-methylcytidine

CAS: 113886-71-8

Formula: C₁₂H₁₇N₃O₆

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 299.28

Ref: 7W-GN8258

N4-Acetyl-2'-O-Methylcytidine

CAS: 113886-71-8

Formula: C₁₂H₁₇N₃O

Molecular weight: 299.28

Ref: 4Z-A-267084

N4-Acetyl-2'-O-methylcytidine

CAS: 113886-71-8

N4-Acetyl-2'-O-methylcytidine is a chemical compound that is an analog of cytidine. It has been shown to have the ability to stabilize RNA molecules at high temperatures and has been used in the study of epigenetics and thermophilic organisms. N4-Acetyl-2'-O-methylcytidine is also known as AEMC. This compound can be used for reversed phase high performance liquid chromatography, which separates compounds based on their size and shape. Furiosus is a strain of bacteria that contains this chemical compound in its genome. Furiosus was found to contain this compound in its DNA by using posttranscriptional modification techniques such as high performance liquid chromatography (HPLC) and proton nuclear magnetic resonance (NMR).

Formula: C₁₂H₁₇N₃O₆

Purity: Min. 95%

Color and Shape: White Off-White Powder

Molecular weight: 299.29 g/mol

Ref: 3D-NA08375

N4-ACETYL-2′-O-METHYL-CYTIDINE

CAS: 113886-71-8

Formula: C₁₂H₁₇N₃O₆

Purity: 97%

Color and Shape: Liquid, No data available.

Molecular weight: 299.283

Ref: 10-F334268

N4-Acetyl-2’-O-methyl-cytidine

Controlled Product

CAS: 113886-71-8

Applications N4-Acetyl-2’-O-methyl-cytidine is a useful compound in the synthesis of functionalized oligonucleotides.
References Jezowska, M., et al.: Bioconjugate Chem., 27, 2620 (2016)

Formula: C₁₂H₁₇N₃O₆

Color and Shape: Neat

Molecular weight: 299.29

Ref: TR-N633025