CAS 113886-72-9: 2′-O-Methyl-2-thiouridine

Description:2′-O-Methyl-2-thiouridine is a modified nucleoside that features a methyl group at the 2′ position of the ribose sugar and a sulfur atom replacing the oxygen at the 2 position of the uracil base. This modification enhances the stability of RNA molecules and can influence their biological activity, making them resistant to enzymatic degradation. The presence of the methyl group contributes to the overall hydrophobic character of the molecule, which can affect its interactions with proteins and other nucleic acids. 2′-O-Methyl-2-thiouridine is often utilized in the synthesis of RNA oligonucleotides for research and therapeutic applications, particularly in the development of antisense oligonucleotides and RNA interference technologies. Its unique structural features allow for improved binding affinity and specificity in various biochemical assays. Additionally, this compound may play a role in modulating the immune response, as modified nucleosides are known to influence the recognition of RNA by pattern recognition receptors.

Formula:C₁₀H₁₄N₂O₅S

InChI:InChI=1S/C10H14N2O5S/c1-16-8-7(15)5(4-13)17-9(8)12-3-2-6(14)11-10(12)18/h2-3,5,7-9,13,15H,4H2,1H3,(H,11,14,18)/t5-,7-,8-,9-/m1/s1

InChI key:InChIKey=WARUUAMZJXEUEA-ZOQUXTDFSA-N

SMILES:O=C1C=CN(C(=S)N1)C2OC(CO)C(O)C2OC

Synonyms:
2′-O-Methyl-2-thiouridine
Uridine, 2′-O-methyl-2-thio-

Found 3 products.

Product data	Purity	Price range	Estimated delivery
Uridine, 2'-O-methyl-2-thio- REF: IN-DA0009ZHCAS: 113886-72-9	95%	To inquire	Mon 03 Mar 25
2'-O-Methyl-2-thiouridine REF: TM-TNU0130CAS: 113886-72-9	99.89%	185.00 €~1,872.00 €	Thu 06 Mar 25
2'-O-Methyl-2-thiouridine REF: 3D-NM159407CAS: 113886-72-9	Min. 95%	532.00 €~1,429.00 €	Fri 14 Mar 25