CAS 113932-41-5

Tematropium

Description:

Tematropium is a synthetic quaternary ammonium compound primarily used as a bronchodilator in the treatment of respiratory conditions such as chronic obstructive pulmonary disease (COPD) and asthma. It functions as an anticholinergic agent, inhibiting the action of acetylcholine on muscarinic receptors in the airways, leading to relaxation of bronchial smooth muscle and improved airflow. Tematropium is characterized by its relatively long duration of action, which allows for once-daily dosing. The compound is typically administered via inhalation, ensuring targeted delivery to the lungs while minimizing systemic side effects. Its chemical structure includes a tropane ring, contributing to its pharmacological properties. As with other anticholinergics, potential side effects may include dry mouth, constipation, and urinary retention, particularly in sensitive populations. Overall, Tematropium represents a valuable therapeutic option in managing obstructive airway diseases, enhancing patient quality of life through improved respiratory function.

Formula: C₂₁H₃₁NO₈S

InChI: InChI=1/C20H28NO4.CH4O4S/c1-4-24-19(22)18(14-8-6-5-7-9-14)20(23)25-17-12-15-10-11-16(13-17)21(15,2)3;1-5-6(2,3)4/h5-9,15-18H,4,10-13H2,1-3H3;1H3,(H,2,3,4)/q+1;/p-1

Synonyms:

• Tematropium methylsulfate [USAN]
• 3alpha-Hydroxy-8-methyl-1alphaH,5alphaH-tropanium methyl sulfate (salt), (+-)-ethyl hydrogen phenylmalonate
• 8-Azoniabicyclo(3.2.1)octane, 3-(3-ethoxy-1,3-dioxo-2-phenylpropoxy)-8,8-dimethyl-, endo-(+-)-, methyl sulfate
• Tematropium methylsulfate
• Unii-2T52M232D8
• 3-[(3-Ethoxy-3-Oxo-2-Phenylpropanoyl)Oxy]-8,8-Dimethyl-8-Azoniabicyclo[3.2.1]Octane Methyl Sulfate

Tematropium

CAS: 113932-41-5

Tematropium

Purity: ≥98%

Molecular weight: 457.54g/mol

Ref: 54-BUP02422

Tematropium methylsulfate

CAS: 113932-41-5

Tematropium methylsulfate is a potent anticholinergic drug that inhibits the enzyme acetylcholinesterase. This drug is used for the treatment of inflammatory diseases, such as asthma and chronic obstructive pulmonary disease. It has been shown to inhibit the production of pergolide mesylate, which leads to an increase in acetylcholine in the brain. Tematropium methylsulfate has also been shown to have neuroprotective effects, which may be due to its ability to inhibit the destruction of acetylcholine by acetylcholinesterase and enhance the release of acetylcholine from nerve endings.

Formula: C₂₁H₃₁NO₈S

Purity: Min. 95%

Molecular weight: 457.5 g/mol

Ref: 3D-NEA93241

Tematropium

CAS: 113932-41-5

Tematropium (CDDD3602) possesses anticholinergic effects and can be used in neurological studies.

Formula: C₂₁H₃₁NO₈S

Purity: 99.89%

Color and Shape: Solid

Molecular weight: 457.54

Ref: TM-T10732