CAS 113994-45-9

O-Des[2-aMinoethyl]-O-carboxyMethyl-dehydroaMlodipine

Description:

O-Des[2-aminoethyl]-O-carboxymethyl-dehydroamlodipine, identified by its CAS number 113994-45-9, is a chemical compound that belongs to the class of dihydropyridine derivatives, which are commonly used in pharmacology, particularly as calcium channel blockers. This compound features a complex structure that includes functional groups such as carboxymethyl and aminoethyl, which contribute to its biological activity. Typically, compounds in this category exhibit properties that can influence vascular smooth muscle relaxation and lower blood pressure, making them significant in the treatment of hypertension and related cardiovascular conditions. The presence of the dehydro group suggests that it may have altered pharmacokinetic properties compared to its parent compound, amlodipine. Additionally, the specific modifications in its structure may enhance its solubility or bioavailability. As with many pharmaceutical compounds, the safety, efficacy, and mechanism of action would be determined through rigorous clinical studies and regulatory assessments.

Formula: C₂₀H₂₀ClNO₇

Synonyms:

• 2-[[4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methylpyridin-2-yl]methoxy]acetic acid
• Amlodipine Metabolite 4
• AMlodipine Metabolite
• Amlodipine impurities1737
• 3,5-Pyridinedicarboxylic acid, 2-[(carboxymethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-, 3-ethyl 5-methyl ester
• O-Des[2-aMinoethyl]-O-carboxyMethyl-dehydroaMlodipine

Amlodipine Metabolite 4

CAS: 113994-45-9

Formula: C₂₀H₂₀ClNO₇

Color and Shape: White To Off-White Solid

Molecular weight: 421.83

Ref: 4Z-A-0822

O-Des[2-aminoethyl]-O-carboxymethyl dehydroamlodipine

CAS: 113994-45-9

O-Des[2-aminoethyl]-O-carboxymethyl dehydroamlodipine is a major metabolite of the calcium channel inhibitor amlodipine .1

Formula: C₂₀H₂₀ClNO₇

Color and Shape: Solid

Molecular weight: 421.83

Ref: TM-T35602

O-Des[2-aminoethyl]-O-carboxymethyl dehydroamlodipine

Controlled Product

CAS: 113994-45-9

Applications O-Des[2-aminoethyl]-O-carboxymethyl-dehydroamlodipine is the metablolite of Amlodipine (A633495), a long-acting calcium channel blocker that is commonly used as an anti-hypertensive in the treatment of cardiovascular conditions.
References Arrowsmith, J.E., et al.: J. Med. Chem., 29, 1696 (1986), Burges, R.A., et al.: J. Cardiovasc. Pharmacol., 9, 110 (1987), Haria, M., et al.: Drugs, 50, 560 (1995),

Formula: C₂₀H₂₀ClNO₇

Color and Shape: Neat

Molecular weight: 421.83

Ref: TR-D289480

O-Des[2-aminoethyl]-O-carboxymethyl dehydroamlodipine Hydrochloride

Controlled Product

CAS: 113994-45-9

Formula: C₂₀H₂₀ClNO₇•HCl

Color and Shape: Neat

Molecular weight: 421.83 + 36.46

Ref: TR-D289482

O-Des[2-aminoethyl]-O-carboxymethyl dehydroamlodipine

CAS: 113994-45-9

Formula: C₂₀H₂₀ClNO₇

Molecular weight: 421.83

Ref: ST-EA-CP-A5051