CAS 1140517-08-3

ML604440

CAS: 1140517-08-3

ML604440 is a cell permeable proteasome β1i (LMP2) subunit inhibitor.

Formula: C₁₇H₂₄BF₃N₂O₄

Purity: 97.06%

Color and Shape: Solid

Molecular weight: 388.19

Ref: TM-T12079

ML604440

CAS: 1140517-08-3

ML604440

Purity: ≥95%

Molecular weight: 388.19g/mol

Ref: 54-BUP04242

ML604440

CAS: 1140517-08-3

ML604440 is a potent inhibitor of cyclin-dependent kinases (CDKs) and has shown anti-cancer activity in various human cancer cell lines. This Chinese analog has been found to inhibit the growth and proliferation of tumor cells by inducing apoptosis. ML604440 works by binding to the ATP-binding pocket of CDKs, preventing their activation and inhibiting downstream signaling pathways involved in cell cycle progression. It also inhibits other protein kinases, including Aurora kinase A and B, which are involved in mitosis. ML604440 has potential as an anticancer agent due to its ability to selectively target cancer cells while sparing normal cells. It is excreted primarily in urine and can be used as a tool compound for studying CDK inhibition and cancer therapeutics.

Formula: C₁₇H₂₄BF₃N₂O₄

Purity: Min. 95%

Molecular weight: 388.2 g/mol

Ref: 3D-QVB51708