CAS 1140909-48-3: cabozantinib (S)-malate

Description: Cabozantinib (S)-malate is a small molecule inhibitor primarily used in cancer therapy, particularly for treating advanced renal cell carcinoma and hepatocellular carcinoma. It functions as a tyrosine kinase inhibitor, targeting multiple pathways involved in tumor growth and metastasis, including MET, VEGFR, and AXL. The (S)-malate form indicates that the compound is a salt derived from the malic acid, which enhances its solubility and bioavailability. Cabozantinib exhibits a complex structure that includes a central core with various functional groups, contributing to its pharmacological activity. The compound is typically administered orally and has a specific pharmacokinetic profile, including absorption, distribution, metabolism, and excretion characteristics that are crucial for its therapeutic efficacy. Side effects may include gastrointestinal disturbances, fatigue, and hypertension, reflecting its mechanism of action on vascular and cellular pathways. Overall, cabozantinib (S)-malate represents a significant advancement in targeted cancer therapies, offering a multifaceted approach to inhibit tumor progression.

Formula: C₂₈H₂₄FN₃O₅.C₄H₆O₅

InChI: InChI=1S/C28H24FN3O5.C4H6O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18;5-2(4(8)9)1-3(6)7/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34);2,5H,1H2,(H,6,7)(H,8,9)/t;2-/m.0/s1

InChI key: InChIKey=HFCFMRYTXDINDK-WNQIDUERSA-N

SMILES: O=C(O)CC(O)C(=O)O.O=C(NC1=CC=C(F)C=C1)C2(C(=O)NC3=CC=C(OC=4C=CN=C5C=C(OC)C(OC)=CC54)C=C3)CC2

Synonyms:

• (2S)-2-Hydroxybutanedioic acid compd.with N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide(1:1)
• (2S)-2-hydroxybutanedioic acid
• Butanedioic acid, 2-hydroxy-, (2S)-, compd. with N-[4-[(6,7-dimethoxy-4- quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1)
• Cabozantinib L-(-)-Apple Acid
• Cabozantinib L-Malate
• Cabozantinib Malate
• Cometriq
• N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide mono[(2S)-2-hydroxybutanedioate]
• N1-[4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl]-N1'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
• Xl 184

Butanedioic acid, 2-hydroxy-, (2S)-, compd. with N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1)

CAS: 1140909-48-3

• Formula: C₃₂H₃₀FN₃O₁₀
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 635.5931

Cabozantinib S-malate

CAS: 1140909-48-3

• Purity: 98.87%
• Molecular weight: 635.59g/mol

Cabozantinib (S)-Malate

CAS: 1140909-48-3

• Formula: C₂₈H₂₄FN₃O₅·C₄H₆O₅
• Color and Shape: White To Off-White Solid
• Molecular weight: 501.51 134.09

Cabozantinib (S)-Malate

CAS: 1140909-48-3

• Formula: C₂₈H₂₄FN₃O₅·C₄H₆O₅
• Color and Shape: Neat
• Molecular weight: 635.59

Cabozantinib S-malate

CAS: 1140909-48-3

Cabozantinib S-malate (XL184) is the salt form of cabozantinib, an orally bioavailable, small molecule RTK …

• Formula: C₃₂H₃₀FN₃O₁₀
• Purity: 100% - 99.41%
• Color and Shape: Solid
• Molecular weight: 635.59

Cabozantinib malate

CAS: 1140909-48-3

• Formula: C₃₂H₃₀FN₃O₁₀
• Purity: ≥ 98.0%
• Color and Shape: White to off-white powder
• Molecular weight: 635.59

Cabozantinib (Phenylene-d4) L-Malate Salt

CAS: 1140909-48-3

Applications Cabozantinib-d4 L-Malate Salt, is the labeled analogue of Cabozantinib L-Malate Salt (C051500), which is …

• Formula: C₂₈D₄H₂₀FN₃O₅·C₄H₆O₅
• Color and Shape: Neat
• Molecular weight: 639.62

Cabozantinib L-Malate Salt

CAS: 1140909-48-3

Applications Cabozantinib is a small molecule C-Met modulator. Cabozantinib acts as a potent multitargeted VEGFR2, …

• Formula: C₂₈H₂₄FN₃O₅·C₄H₆O₅
• Color and Shape: Neat
• Molecular weight: 635.59

Cabozantinib malate

CAS: 1140909-48-3

Inhibits MET, VEGFR1, VEGFR2; VEGFR3 receptor tyrosine kinases; antineoplastic

• Formula: C₂₈H₂₄FN₃O₅·C₄H₆O₅
• Purity: Min. 95%
• Color and Shape: Off-White Powder
• Molecular weight: 635.6 g/mol