CAS 114319-04-9

5-fluoro-4-thio-2'-deoxyuridylate

Description:

5-Fluoro-4-thio-2'-deoxyuridylate is a nucleoside analog that plays a significant role in the field of medicinal chemistry, particularly in the development of antiviral and anticancer agents. This compound is characterized by the presence of a fluorine atom at the 5-position and a thio group at the 4-position of the uracil base, which alters its biological activity compared to natural nucleotides. The modification enhances its ability to interfere with nucleic acid synthesis, making it a potential inhibitor of DNA polymerases. Its structural features contribute to its stability and affinity for target enzymes, which can lead to cytotoxic effects in rapidly dividing cells. The compound is typically studied for its pharmacological properties, including its mechanism of action, efficacy, and potential side effects. Additionally, its unique chemical structure allows for further derivatization, which can be explored to improve its therapeutic profile. Overall, 5-fluoro-4-thio-2'-deoxyuridylate represents a valuable tool in the ongoing research for effective treatments against various diseases.

Formula: C₉H₁₂FN₂O₇PS

InChI: InChI=1/C9H12FN2O7PS/c10-4-2-12(9(14)11-8(4)21)7-1-5(13)6(19-7)3-18-20(15,16)17/h2,5-7,13H,1,3H2,(H,11,14,21)(H2,15,16,17)/t5-,6+,7+/m0/s1

Synonyms:

• 4-Thio-5-fdump
• 4-Thio-5-fluoro-dump
• 5-Fluoro-4-thio-2'-deoxyuridine 5'-monophosphate
• 5-Fluoro-4-thio-2'-dump
• 5'-Uridylic acid, 2'-deoxy-5-fluoro-4-thio-
• 1-(2-deoxy-5-O-phosphono-beta-D-erythro-pentofuranosyl)-5-fluoro-4-thioxo-3,4-dihydropyrimidin-2(1H)-one
• 5-Fluoro-4-thio-2'-deoxyuridylate