CAS 114333-22-1
:N(4)-hydroxy-5-fluorodeoxycytidine monophosphate
Description:
N(4)-hydroxy-5-fluorodeoxycytidine monophosphate, commonly referred to as 4-hydroxy-5-fluorodeoxycytidine monophosphate (or 4-OH-5-FdCMP), is a nucleotide analog that plays a significant role in the study of nucleic acid metabolism and cancer therapeutics. This compound is characterized by the presence of a hydroxyl group at the N(4) position and a fluorine atom at the 5 position of the deoxycytidine base, which alters its biological activity compared to natural nucleotides. It exists as a monophosphate, indicating that it has one phosphate group attached, which is crucial for its incorporation into nucleic acids. The structural modifications impart unique properties, such as increased stability against enzymatic degradation and potential interference with DNA synthesis. This compound is of particular interest in research related to antiviral and anticancer drugs, as it can inhibit DNA polymerases and affect cellular proliferation. Its CAS number, 114333-22-1, is a unique identifier that facilitates its recognition in chemical databases and literature.
Formula:C9H13FN3O8P
InChI:InChI=1/C9H13FN3O8P/c10-4-2-13(9(15)11-8(4)12-16)7-1-5(14)6(21-7)3-20-22(17,18)19/h2,5-7,14,16H,1,3H2,(H,11,12,15)(H2,17,18,19)/t5-,6+,7+/m0/s1
Synonyms:- N(4)-Hydroxy-5-fluoro-dcmp
- N(4)-OH-5-Fdcmp
- 5'-Uridylic acid, 2'-deoxy-5-fluoro-, 4-oxime
- 2'-deoxy-5-fluoro-N-hydroxycytidine 5'-(dihydrogen phosphate)
- N(4)-Hydroxy-5-fluorodeoxycytidine monophosphate
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