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CAS 114346-31-5

:

Boc-p-amino-Phe(Fmoc)-OH

Description:
Boc-p-amino-Phe(Fmoc)-OH, also known as Fmoc-p-amino-phenylalanine, is a protected amino acid commonly used in peptide synthesis. It features two protective groups: the Boc (tert-butyloxycarbonyl) group, which protects the amino group, and the Fmoc (9-fluorenylmethoxycarbonyl) group, which protects the carboxylic acid group. This compound is characterized by its stability under basic conditions and its ability to be selectively deprotected under mild acidic conditions, allowing for the sequential assembly of peptides. The presence of the p-amino group on the phenylalanine side chain enhances its reactivity and provides opportunities for further functionalization. The compound is typically used in solid-phase peptide synthesis, where the Fmoc group can be removed to expose the amino group for coupling with other amino acids. Its solubility in organic solvents and moderate solubility in water make it versatile for various synthetic applications. Overall, Boc-p-amino-Phe(Fmoc)-OH is a valuable building block in the field of medicinal chemistry and peptide research.
Formula:C29H30N2O6
InChI:InChI=1/C29H30N2O6/c1-29(2,3)37-28(35)31-25(26(32)33)16-18-12-14-19(15-13-18)30-27(34)36-17-24-22-10-6-4-8-20(22)21-9-5-7-11-23(21)24/h4-15,24-25H,16-17H2,1-3H3,(H,30,34)(H,31,35)(H,32,33)/t25-/m0/s1
SMILES:CC(C)(C)OC(=N[C@@H](Cc1ccc(cc1)NC(=O)OCC1c2ccccc2c2ccccc12)C(=O)O)O
Synonyms:
  • Boc-Phe(4-NHFmoc)-OH
  • Boc-L-4-Aminophenylalanine(Fmoc)
  • N-(tert-butoxycarbonyl)-4-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-L-phenylalanine
  • Boc-4-(Fmoc-amino)-L-phenylalanine >=98.0%
  • N-[(1,1-dimethylethoxy)carbonyl]-4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-L-Phenylalanine
  • Boc-L-phe(Fmoc-4-Amino)-OH
  • N-ALPHA-T-BUTOXYCARBONYL-[4-(9-FLUORENYLMETHOXYCARBONYLAMINO)]-L-PHENYLALANINE
  • (S)-Boc-2-amino-3-(4-Fmoc-aminophenyl)propionoic acid
  • L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]- (9CI)
  • 4-(Fmoc-amino)-N-Boc-L-phenylalanine
  • See more synonyms
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