CAS 1143532-39-1

AZD-5363

Description:

AZD-5363 is a small molecule inhibitor primarily targeting the protein kinase AKT, which plays a crucial role in various cellular processes, including metabolism, proliferation, and survival. This compound is part of a class of drugs known as AKT inhibitors, which have garnered interest in cancer therapy due to their potential to disrupt signaling pathways that promote tumor growth and resistance to treatment. AZD-5363 exhibits selectivity for the AKT isoforms, particularly AKT1, AKT2, and AKT3, and has been studied for its efficacy in various cancer types, including breast and prostate cancers. The compound is typically administered orally and has undergone clinical trials to evaluate its safety, tolerability, and therapeutic effectiveness. Its mechanism of action involves the inhibition of AKT phosphorylation, leading to the suppression of downstream signaling pathways that contribute to cancer cell survival and proliferation. As research continues, AZD-5363 represents a promising avenue for targeted cancer therapy, particularly in tumors with aberrant AKT signaling.

Synonyms:

• 4-Piperidinecarboxamide, 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-
• 4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinecarboxamide

4-Piperidinecarboxamide, 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-

CAS: 1143532-39-1

Formula: C₂₁H₂₅ClN₆O₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 428.9152

Ref: IN-DA000B4O

Capivasertib

CAS: 1143532-39-1

Capivasertib

Purity: ≥95%

Molecular weight: 428.92g/mol

Ref: 54-BUP12094

(S)-4-Amino-N-(1-(4-Chlorophenyl)-3-Hydroxypropyl)-1-(7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)Piperidine-4-Carboxamide

CAS: 1143532-39-1

(S)-4-Amino-N-(1-(4-Chlorophenyl)-3-Hydroxypropyl)-1-(7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)Piperidine-4-Carboxamide

Purity: 98%

Molecular weight: 428.92g/mol

Ref: 54-OR1023042

Capivasertib

CAS: 1143532-39-1

Formula: C₂₁H₂₅ClN₆O₂

Molecular weight: 428.92

Ref: 4Z-C-444001

Capivasertib

CAS: 1143532-39-1

Capivasertib (AZD5363) is a broad-spectrum AKT inhibitor with inhibitory activity against Akt1, Akt2, and Akt3 (IC50=3/7/7 nM) with oral activity.

Formula: C₂₁H₂₅ClN₆O₂

Purity: 97.59% - 99.6%

Color and Shape: Solid

Molecular weight: 428.92

Ref: TM-T1920

AZD5363

Controlled Product

CAS: 1143532-39-1

Applications AZD5363 is used in inhibiting the proliferation of certain tumor cell lines.
References Wu, X. et al.: J. Translat. Med., 10, 180 (2012); Davies, B. et al.: Mol. Canc. Ther., 11, 873 (2012);

Formula: C₂₁H₂₅ClN₆O₂

Color and Shape: Neat

Molecular weight: 428.92

Ref: TR-A808135

Capivasertib

CAS: 1143532-39-1

Purity: 98%

Molecular weight: 428.9200134

Ref: 10-F861532

AZD 5363

CAS: 1143532-39-1

AZD 5363, also called Capivasertib, inhibits AKT1, AKT2, AKT3, P70S6K and PKA. A pyrrolopyrimidine derivative with antineoplastic activity.

Formula: C₂₁H₂₅ClN₆O₂

Purity: Min. 95%

Molecular weight: 428.92 g/mol

Ref: 3D-FA29493