CAS 114560-48-4

Apaziquone

Description:

Apaziquone, with the CAS number 114560-48-4, is a chemical compound primarily studied for its potential use in cancer therapy, particularly in the treatment of superficial bladder cancer. It is a prodrug, meaning it is converted into an active form within the body, which then exerts its therapeutic effects. Apaziquone is characterized by its ability to undergo bioreductive activation, leading to the formation of reactive species that can induce cytotoxicity in tumor cells. This mechanism is particularly advantageous in hypoxic tumor environments, where many conventional therapies may be less effective. The compound is typically administered intravesically, allowing for localized treatment while minimizing systemic exposure and side effects. Its chemical structure includes a quinone moiety, which is integral to its reactivity and therapeutic action. Ongoing research continues to evaluate its efficacy, safety profile, and potential combination with other therapeutic agents to enhance treatment outcomes in oncology.

Formula: C₁₅H₁₆N₂O₄

InChI: InChI=1S/C15H16N2O4/c1-16-10(3-2-6-18)9(8-19)13-14(16)12(20)7-11(15(13)21)17-4-5-17/h2-3,7,18-19H,4-6,8H2,1H3/b3-2+

InChI key: InChIKey=MXPOCMVWFLDDLZ-NSCUHMNNSA-N

SMILES: C(O)C=1C2=C(N(C)C1/C=C/CO)C(=O)C=C(C2=O)N3CC3

Synonyms:

• 1H-Indole-4,7-dione, 5-(1-aziridinyl)-3-(hydroxymethyl)-2-(3-hydroxy-1-propenyl)-1-methyl-, (E)-
• 1H-Indole-4,7-dione, 5-(1-aziridinyl)-3-(hydroxymethyl)-2-[(1E)-3-hydroxy-1-propen-1-yl]-1-methyl-
• 1H-Indole-4,7-dione, 5-(1-aziridinyl)-3-(hydroxymethyl)-2-[(1E)-3-hydroxy-1-propenyl]-1-methyl-
• 5-(1-Aziridinyl)-3-(hydroxymethyl)-2-[(1E)-3-hydroxy-1-propen-1-yl]-1-methyl-1H-indole-4,7-dione
• Apaziquone
• EO 9 (pharmaceutical)
• Eo 9
• NSC 382456
• NSC 382459

1H-Indole-4,7-dione, 5-(1-aziridinyl)-3-(hydroxymethyl)-2-[(1E)-3-hydroxy-1-propen-1-yl]-1-methyl-

CAS: 114560-48-4

Formula: C₁₅H₁₆N₂O₄

Molecular weight: 288.2985

Ref: IN-DA000EO2

Apaziquone

CAS: 114560-48-4

Apaziquone may fight cancer, sensitizes to radiation, and kills tumor cells by DNA alkylation under low oxygen conditions.

Formula: C₁₅H₁₆N₂O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 288.30

Ref: TM-T21316

Apaziquone

CAS: 114560-48-4

Formula: C₁₅H₁₆N₂O₄

Molecular weight: 288.31

Ref: 4Z-A-114001

Apaziquone

Controlled Product

CAS: 114560-48-4

Formula: C₁₅H₁₆N₂O₄

Color and Shape: Neat

Molecular weight: 288.298

Ref: TR-A726110

Apaziquone

CAS: 114560-48-4

Apaziquone is a new compound that contains two nitrogen atoms and a dinucleotide phosphate. It has been shown to be effective in treating intravesical radiation-induced cystitis, as well as other types of bladder cancer. Apaziquone has minimal toxicity and is stable under various experimental conditions.

Formula: C₁₅H₁₆N₂O₄

Purity: Min. 95%

Molecular weight: 288.3 g/mol

Ref: 3D-PEA56048

Apaziquone

CAS: 114560-48-4

Formula: C₁₅H₁₆N₂O₄

Molecular weight: 288.31

Ref: ST-EA-CP-A247000