CAS 114616-10-3

N(alpha),N(im)-di-fmoc-L-histidine pen-tafluorophenyl ester

Description:

N(alpha),N(im)-di-fmoc-L-histidine pentafluorophenyl ester is a derivative of the amino acid histidine, modified to enhance its reactivity and stability for various applications, particularly in peptide synthesis. The "Fmoc" (9-fluorenylmethoxycarbonyl) groups serve as protective groups for the amino functionalities, allowing for selective deprotection during synthesis. The presence of the pentafluorophenyl ester moiety significantly increases the electrophilicity of the carboxylic acid, facilitating the formation of peptide bonds. This compound is characterized by its high stability under basic conditions and its ability to undergo rapid coupling reactions with amines, making it a valuable intermediate in the synthesis of peptides and proteins. Additionally, the fluorinated aromatic ring can impart unique properties, such as increased lipophilicity and altered solubility, which can be advantageous in drug development and biochemical applications. Overall, this compound is a useful tool in organic and medicinal chemistry, particularly in the context of peptide synthesis and modification.

Formula: C₄₂H₂₈F₅N₃O₆

Synonyms:

• Fmoc-His(Fmoc)-OPfp

Fmoc-His(Fmoc)-OPfp

CAS: 114616-10-3

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Formula: C₄₂H₂₈N₃O₆F₅

Purity: Min. 95%

Molecular weight: 765.68 g/mol

Ref: 3D-FF111288