CAS 1146699-66-2

Pentanamide,2-[[(4-chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoro-,(2R)-

Description:

Pentanamide, 2-[[(4-chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoro-, (2R)- is a complex organic compound characterized by its multi-functional structure, which includes a pentanamide backbone, a sulfonyl group, and a trifluoromethyl group. The presence of the 4-chlorophenyl moiety contributes to its potential biological activity, while the 1,2,4-oxadiazole ring may enhance its pharmacological properties. This compound is likely to exhibit polar characteristics due to the amide and sulfonyl functionalities, which can influence its solubility and reactivity. The trifluoromethyl group is known to impart unique electronic properties, potentially affecting the compound's interaction with biological targets. Additionally, the stereochemistry indicated by (2R) suggests specific spatial arrangements that may be crucial for its biological efficacy. Overall, this compound's intricate structure suggests potential applications in medicinal chemistry, particularly in the development of pharmaceuticals targeting specific biological pathways.

Formula: C₂₀H₁₇ClF₄N₄O₄S

Synonyms:

• (2R)-2-[N-[(4-Chlorophenyl)sulfonyl]-N-[[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide
• (2R)-2-[(4-chlorophenyl)sulfonyl-[[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoro-pentanamide
• Avagacestat
• Bms-708163

Pentanamide, 2-[[(4-chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoro-, (2R)-

CAS: 1146699-66-2

Formula: C₂₀H₁₇ClF₄N₄O₄S

Purity: 99%

Color and Shape: Solid

Molecular weight: 520.8850

Ref: IN-DA000EZW

Avagacestat

CAS: 1146699-66-2

Avagacestat

Purity: ≥98%

Molecular weight: 520.89g/mol

Ref: 54-BUP09478

(R)-2-((4-Chloro-N-(2-Fluoro-4-(1,2,4-Oxadiazol-3-Yl)Benzyl)Phenyl)Sulfonamido)-5,5,5-Trifluoropentanamide

CAS: 1146699-66-2

(R)-2-((4-Chloro-N-(2-Fluoro-4-(1,2,4-Oxadiazol-3-Yl)Benzyl)Phenyl)Sulfonamido)-5,5,5-Trifluoropentanamide

Purity: 98%

Molecular weight: 520.89g/mol

Ref: 54-PC108758

Avagacestat

CAS: 1146699-66-2

Avagacestat (BMS-708163) (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM,

Formula: C₂₀H₁₇ClF₄N₄O₄S

Purity: 98.87% - 99.73%

Color and Shape: Solid

Molecular weight: 520.89

Ref: TM-T6249

(R)-2-[[4-chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide

Controlled Product

CAS: 1146699-66-2

Applications Avagacestat acts as a γ-secretase inhibitor allowing for treatment of ALzheimer’s disease. On addition it has seen uses targeting embryonic signaling pathways, which control stem cell and cellular development process in cancer therapy.
References Harris, PJ. et al.: Expert. Opin. Ther. Tar., 16, 131 (2012); Gilman, K.W. et al.: ACS Med. Chem. Lett., 1, 120 (2010);

Formula: C₂₀H₁₇ClF₄N₄O₄S

Color and Shape: Neat

Molecular weight: 520.88

Ref: TR-C379830

BMS 708163

CAS: 1146699-66-2

Inhibitor of γ-secretase; Alzheimer's disease treatment

Formula: C₂₀H₁₇ClF₄N₄O₄S

Purity: Min. 95%

Molecular weight: 520.89 g/mol

Ref: 3D-FA43361