CAS 114719-57-2

Fascaplysin

Description:

Fascaplysin is a natural compound classified as a marine alkaloid, primarily derived from certain species of marine sponges. It is known for its complex structure, which includes multiple rings and functional groups that contribute to its biological activity. Fascaplysin exhibits notable pharmacological properties, including cytotoxicity against various cancer cell lines, making it a subject of interest in medicinal chemistry and drug development. Its mechanism of action is thought to involve the disruption of cellular processes, although specific pathways are still under investigation. Additionally, Fascaplysin has shown potential as an anti-inflammatory agent. The compound's solubility and stability can vary depending on the solvent and environmental conditions, which is crucial for its application in biological studies. As research continues, Fascaplysin may offer insights into new therapeutic strategies, particularly in oncology. However, further studies are needed to fully understand its efficacy, safety, and potential side effects in clinical settings.

Formula: C₁₈H₁₁ClN₂O

InChI: InChI=1/C18H10N2O/c21-18-13-6-2-4-8-15(13)20-10-9-12-11-5-1-3-7-14(11)19-16(12)17(18)20/h1-10H/p+1

InChI key: InChIKey=PWUOOJVYZQILBG-UHFFFAOYSA-N

SMILES: O=C1C=2C3=C(C=4C(N3)=CC=CC4)C=C[N+]2C=5C1=CC=CC5.[Cl-]

Synonyms:

• 13-Oxo-12,13-Dihydropyrido[1,2-A:3,4-B']Diindol-5-Ium
• 13-Oxo-12,13-Dihydropyrido[1,2-A:3,4-B']Diindol-5-Ium Chloride
• Fascaplysin
• Fascaplysin chloride hydrate
• Fascaplysine
• Fascaplysine hydrate, Pyrido[1,2-a:3,4-b]diindol-5-ium,12,13-dihydro-13-oxo-, chloride (9CI)
• NSC 622398
• Pyrido[1,2-a:3,4-b′]diindol-5-ium, 12,13-dihydro-13-oxo-, chloride
• Fascaplysin chloride
• Fascaplysin (chloride)|CDK4 inhibitor
• 12,13-dihydro-13-oxo-pyrido[1,2-a:3,4-b']diindol-5-ium,monochloride

Pyrido[1,2-a:3,4-b']diindol-5-ium, 12,13-dihydro-13-oxo-, chloride

CAS: 114719-57-2

Formula: C₁₈H₁₁ClN₂O

Color and Shape: Solid

Molecular weight: 306.7457

Ref: IN-DA000F3H

Fascaplysin

CAS: 114719-57-2

Formula: C₁₈H₁₁N₂O

Purity: ≥ 97%

Color and Shape: Dark red-brown solid

Molecular weight: 271.29

Ref: 7W-GP0025

Fascaplysin chloride

CAS: 114719-57-2

Fascaplysin inhibits CDK4/D1 (IC50=0.35μM), triggers caspase-activated autophagy-apoptosis crosstalk, and blocks PI3K/AKT/mTOR in HL-60 cells.

Formula: C₁₈H₁₁ClN₂O

Color and Shape: Solid

Molecular weight: 306.75

Ref: TM-T27305

Fascaplysin Chloride

Controlled Product

CAS: 114719-57-2

Applications Fascaplysin Chloride is a selective CDK4/cyclin D1 inhibitor. Downregulates the PI3K pathway in cancer cells and also has an effect on erythrocytes and thrombosis.
References Dighe, S. et al.: Tetrahedron., 73, 2455 (2017);

Formula: C₁₈H₁₁N₂O•Cl

Color and Shape: Neat

Molecular weight: 271.3 + (35.45)

Ref: TR-F150013