CAS 114778-60-8

9-(3-hydroxypropoxy)guanine

Description:

9-(3-Hydroxypropoxy)guanine is a synthetic nucleoside analog characterized by the presence of a guanine base linked to a 3-hydroxypropoxy side chain. This compound is notable for its potential applications in medicinal chemistry, particularly in the development of antiviral and anticancer agents. The hydroxypropoxy group enhances the solubility and bioavailability of the molecule, which may improve its efficacy in biological systems. As a guanine derivative, it can participate in nucleic acid interactions, potentially influencing DNA and RNA synthesis. The compound's structure allows it to mimic natural nucleosides, which can lead to its incorporation into nucleic acids, thereby affecting cellular processes. Its CAS number, 114778-60-8, is a unique identifier that facilitates the tracking and study of this compound in scientific literature and databases. Overall, 9-(3-hydroxypropoxy)guanine represents a significant area of interest in pharmaceutical research due to its structural properties and biological implications.

Formula: C₈H₁₁N₅O₃

InChI: InChI=1/C8H11N5O3/c9-8-11-6-5(7(15)12-8)10-4-13(6)16-3-1-2-14/h4,14H,1-3H2,(H3,9,11,12,15)

SMILES: C(CO)COn1cnc2c1[nH]c(=N)nc2O

Synonyms:

• Brl 44385
• 2-Amino-1,9-dihydro-9-(3-hydroxypropoxy)-6H-purin-6-one
• 6H-Purin-6-one, 2-amino-1,9-dihydro-9-(3-hydroxypropoxy)-
• 2-amino-9-(3-hydroxypropoxy)-3,9-dihydro-6H-purin-6-one
• 9-(3-Hydroxypropoxy)guanine

6H-Purin-6-one, 2-amino-1,9-dihydro-9-(3-hydroxypropoxy)-

CAS: 114778-60-8

Formula: C₈H₁₁N₅O₃

Molecular weight: 225.2046

Ref: IN-DA000F6M

9-(3-Hydroxypropoxy)guanine

CAS: 114778-60-8

9-(3-Hydroxypropoxy)guanine is an aldehyde oxidase inhibitor that blocks the production of formaldehyde, which is a reactive metabolite that can cause DNA damage. 9-(3-Hydroxypropoxy)guanine has been shown to inhibit the oxidation of purines in incubations with c1-6 alkyl. It also inhibits the oxidation of guanine and deoxyguanine mediated by aldehyde oxidase. This drug is a prodrug, which is converted to its active form in the cytosol by cytochrome p450 enzymes. The metabolic transformation of 9-(3-hydroxypropoxy)guanine into its active form occurs primarily in hepatocytes. 9-(3-Hydroxypropoxy)guanine has been shown to be effective against oxidative stress induced by homogenates and liver cells from humans, as well as cytosolic extracts from human hepatocytes.

Formula: C₈H₁₁N₅O₃

Purity: Min. 95%

Molecular weight: 225.2 g/mol

Ref: 3D-PEA77860

BRL44385

CAS: 114778-60-8

BRL44385 is an effective and selective inhibitor of the replication of HSV-1 and HSV2, Epstein-Barr virus (EBV), and varicella-zoster virus (VZV).

Formula: C₈H₁₁N₅O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 225.2

Ref: TM-T10615