CAS 1148-11-4

Benzyloxycarbonyl-L-proline

Description:

Benzyloxycarbonyl-L-proline, commonly referred to as Z-Proline, is a derivative of the amino acid proline, characterized by the presence of a benzyloxycarbonyl (Z) protecting group. This compound is typically used in peptide synthesis as a protecting group for the amino functionality of proline, which helps to prevent unwanted reactions during the synthesis process. Z-Proline is a white to off-white crystalline solid that is soluble in organic solvents such as methanol and dimethyl sulfoxide, but has limited solubility in water. Its molecular structure includes a proline backbone, which contributes to its unique conformational properties, making it valuable in the design of peptides and proteins. The compound is stable under normal laboratory conditions but may undergo hydrolysis or deprotection under acidic or basic conditions. Due to its role in peptide chemistry, Z-Proline is significant in pharmaceutical research and the development of biologically active compounds. Safety data should be consulted for handling, as with any chemical substance.

Formula: C₁₃H₁₅NO₄

InChI: InChI=1S/C13H15NO4/c15-12(16)11-7-4-8-14(11)13(17)18-9-10-5-2-1-3-6-10/h1-3,5-6,11H,4,7-9H2,(H,15,16)/t11-/m0/s1

InChI key: InChIKey=JXGVXCZADZNAMJ-NSHDSACASA-N

SMILES: C(OCC1=CC=CC=C1)(=O)N2[C@H](C(O)=O)CCC2

Synonyms:

• (2S)-1,2-Pyrrolidinedicarboxylic acid 1-(phenylmethyl) ester
• (2S)-1-(Benzyloxycarbonyl)pyrrolidine-2-carboxylic acid
• (2S)-1-Phenylmethoxycarbonylpyrrolidine-2-carboxylic acid
• (2S)-1-[(benzyloxy)carbonyl]pyrrolidine-2-carboxylate
• (S)-1-(Benzyloxycarbonyl)pyrrolidine-2-carboxylic acid
• 1,2-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl) ester, (2S)-
• 1,2-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl) ester, (S)-
• 1,2-Pyrrolidinedicarboxylic acid, 1-benzyl ester, <span class="text-smallcaps">L</span>-
• 1,2-Pyrrolidinedicarboxylic acid, 1-benzyl ester, L-
• 1-(Benzyloxycarbonyl)-<span class="text-smallcaps">L</span>-proline
• 1-(Benzyloxycarbonyl)-L-proline
• 1-Carbobenzoxy-<span class="text-smallcaps">L</span>-proline
• 1-Carbobenzoxy-L-proline
• 1-[(Benzyloxy)Carbonyl]Proline
• 1-[(benzyloxy)carbonyl]-D-proline
• 1-[(benzyloxy)carbonyl]-L-proline
• <span class="text-smallcaps">L</span>-Cbz-Proline
• Benzyloxycarbonyl-<span class="text-smallcaps">L</span>-proline
• Benzyloxycarbonyl-L-proline
• Carbobenzoxy-<span class="text-smallcaps">L</span>-proline
• Carbobenzoxy-L-proline
• Carbobenzoxy-S-proline
• Carbobenzyloxy-<span class="text-smallcaps">L</span>-proline
• Carbobenzyloxy-L-proline
• Cbz-<span class="text-smallcaps">L</span>-Pro-OH
• Cbz-L-Pro-OH
• Cbz-L-proline
• N-(Benzyloxycarbonyl)-<span class="text-smallcaps">L</span>-proline
• N-(Carbobenzyloxy)-<span class="text-smallcaps">L</span>-proline
• N-Benzyloxycarbonyl-(S)-proline
• N-Benzyloxycarbonyl-L-prolin
• N-Benzyloxycarbonyl-L-proline
• N-CBZ-L-Proline N-Carbobenzyloxy-L-proline
• N-Carbobenzoxy-<span class="text-smallcaps">L</span>-proline
• N-Carbobenzoxy-L-proline
• N-Carbobenzyloxy-(S)-proline
• N-Cbz-<span class="text-smallcaps">L</span>-proline
• N-Cbz-L-Pro-OH
• N-Cbz-L-proline
• N-[(Phenylmethoxy)carbonyl]-<span class="text-smallcaps">L</span>-proline
• N-[(Phenylmethoxy)carbonyl]-L-proline
• N-benciloxicarbonil-L-prolina
• N-cbz-L-proline crystalline
• Z-L-Proline
• Z-Pro-OH
• N-CARBOBENZYLOXY-L-PROLINE
• N-ALPHA-BENZYLOXYCARBONYL-L-PROLINE
• N-ALPHA-CBZ-L-PROLINE
• (2S)-1-[(BENZYLOXY)CARBONYL]PYRROLIDINE-2-CARBOXYLIC ACID
• CBZ-PRO-OH
• N-ALPHA-CARBOBENZOXY-L-PROLINE
• (S)-N-CBZ-PYRROLIDINE-2-CARBOXYLIC ACID
• N-CBZ-L-PROLINE-OH
• Z-L-PRO-OH
• N-ALPHA-CARBOBENZOXY-L-PYRROLIDINE-2-CARBOXYLIC ACID
• L-CBZ-PROLINE

N-Benzyloxycarbonyl-L-proline

CAS: 1148-11-4

Formula: C₁₃H₁₅NO₄

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 249.27

Ref: 3B-C0713

N-Benzyloxycarbonyl-L-proline, 98+%

CAS: 1148-11-4

N-(Benzyloxycarbonyl)-L-proline is a potent inhibitor of prolidase; a specific peptidase that cleaves dipeptides with a C-terminal prolyl and hydroxylprolyl residue. It is also used in the synthesis of N-(L-Prolyl)--alanine which is a derivative of the naturally occurring beta amino acid -Alanine. T

Formula: C₁₃H₁₄NO₄

Purity: 98+%

Color and Shape: Powder or crystalline powder or crystals or granules, White to cream

Molecular weight: 248.26

Ref: 02-B21672

Z-Pro-OH

CAS: 1148-11-4

Bachem ID: 4001343.

Formula: C₁₃H₁₅NO₄

Purity: 99.1%

Color and Shape: White

Molecular weight: 249.27

Ref: 01-4001343

Z-Pro-OH

CAS: 1148-11-4

Formula: C₁₃H₁₅NO₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 249.2625

Ref: IN-DA007RF9

(2S)-Pyrrolidine-2-carboxylic acid, N-CBZ protected

CAS: 1148-11-4

(2S)-Pyrrolidine-2-carboxylic acid, N-CBZ protected

Formula: C₁₃H₁₅NO₄

Purity: 98%

Color and Shape: white solid

Molecular weight: 249.26g/mol

Ref: 54-OR61280

Carbobenzoxyproline

CAS: 1148-11-4

Carbobenzoxyproline

Purity: ≥98%

Molecular weight: 249.26g/mol

Ref: 54-BUP19312

Z-Pro-OH

CAS: 1148-11-4

Formula: C₁₃H₁₅NO₄

Molecular weight: 249.27

Ref: 7W-GM1976

Carbobenzoxyproline

CAS: 1148-11-4

Carbobenzoxyproline (Carbobenzoxy-S-proline) is a prolidase inhibitor.

Formula: C₁₃H₁₅NO₄

Purity: 99.79%

Color and Shape: White To Light Yellow Crystal Powder

Molecular weight: 249.26

Ref: TM-T20125

Z-Pro-OH

CAS: 1148-11-4

M03066 - Z-Pro-OH

Formula: C₁₃H₁₅NO₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 249.266

Ref: 10-M03066

N-Benzyloxycarbonyl-L-proline

CAS: 1148-11-4

N-Benzyloxycarbonyl-L-proline is a cationic polymerization inhibitor that has been shown to inhibit the growth of Pseudomonas aeruginosa. It inhibits bacterial growth by inhibiting the production of collagen, an important component in the cell wall. N-Benzyloxycarbonyl-L-proline is also used as a histological staining agent and has been shown to be effective against breast cancer cells resistant to tamoxifen therapy.

Formula: C₁₃H₁₅NO₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 249.26 g/mol

Ref: 3D-FB37965

Z-L-Proline extrapure, 99%

CAS: 1148-11-4

Formula: C₁₃H₁₅NO₄

Purity: min. 99%

Color and Shape: White, Crystalline powder

Molecular weight: 249.3

Ref: SR-31688

N-(Benzyloxycarbonyl)-L-proline

Controlled Product

CAS: 1148-11-4

Applications N-(Benzyloxycarbonyl)-L-proline is a potent in vitro and in vivo inhibitor of prolidase; a specific peptidase that cleaves dipeptides with a C-terminal prolyl and hydroxylprolyl residue. N-(Benzyloxycarbonyl)-L-proline is also used in the synthesis of N-(L-Prolyl)-β-alanine (P756190) which is a derivative of the naturally occurring beta amino acid β-Alanine (A637320).
References Lupi, A., et al.: BBA-Mol. Cell Res., 1744, 157 (2005)

Formula: C₁₃H₁₅NO₄

Color and Shape: Neat

Molecular weight: 249.26

Ref: TR-B287810

Acalabrutinib Impurity 18

CAS: 1148-11-4

Formula: C₁₃H₁₅NO₄

Molecular weight: 249.27

Ref: ST-EA-CP-A165007