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CAS 114869-83-9

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Carvedilol b-D-Glucuronide

Description:
Carvedilol b-D-Glucuronide is a metabolite of carvedilol, a non-selective beta-blocker used primarily for the treatment of hypertension and heart failure. This compound is characterized by its glucuronide conjugation, which enhances its solubility and facilitates excretion from the body. The glucuronidation process typically occurs in the liver, where the drug is modified by the addition of glucuronic acid, a reaction catalyzed by UDP-glucuronosyltransferases. As a result, carvedilol b-D-Glucuronide may exhibit altered pharmacokinetic properties compared to its parent compound, including differences in bioavailability and duration of action. The presence of the glucuronide moiety can also influence the compound's interaction with biological targets and its overall therapeutic efficacy. Additionally, understanding the characteristics of this metabolite is crucial for assessing the safety and efficacy of carvedilol therapy, as well as for evaluating potential drug-drug interactions. Overall, carvedilol b-D-Glucuronide plays a significant role in the pharmacological profile of carvedilol.
Formula:C30H34N2O10
InChI:InChI=1/C30H34N2O10/c1-38-21-10-4-5-11-22(21)39-14-13-31-15-17(41-30-27(35)25(33)26(34)28(42-30)29(36)37)16-40-23-12-6-9-20-24(23)18-7-2-3-8-19(18)32-20/h2-12,17,25-28,30-35H,13-16H2,1H3,(H,36,37)/t17?,25-,26-,27-,28?,30+/m0/s1
Synonyms:
  • 2-(9H-Carbazol-4-yloxy)-1-[[[2-(2-methoxyphenoxy)ethyl]amino]methyl]ethyl b-D-Glucopyranosiduronic Acid
  • Carvedilol Glucuronide
  • (Glucopyranosiduronic Acid
  • Carvedilol-D-Glucuronide
  • 2-(9H-Carbazol-4-yloxy)-1-[[[2-(2-methoxyphenoxy)ethyl]amino]methyl]ethyl-D-Glucopyranosiduronic Acid
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