CAS 114899-77-3: Trabectedin

Description: Trabectedin, also known by its developmental code ET-743, is a synthetic alkaloid derived from the marine tunicate Ecteinascidia turbinata. It is primarily used as an antineoplastic agent in cancer therapy, particularly for soft tissue sarcomas and ovarian cancer. Trabectedin functions by binding to DNA and disrupting the transcription process, leading to cell cycle arrest and apoptosis in cancer cells. Its mechanism of action involves the formation of DNA adducts, which interfere with the normal function of the cell's machinery. The compound exhibits a unique structure characterized by a complex polycyclic core and a functionalized side chain, contributing to its biological activity. Trabectedin is administered intravenously and has a specific pharmacokinetic profile, including a relatively short half-life and extensive protein binding. Side effects may include myelosuppression, liver enzyme elevation, and gastrointestinal disturbances. Due to its unique origin and mechanism, Trabectedin represents a significant advancement in targeted cancer therapies, highlighting the potential of marine-derived compounds in medicinal chemistry.

Formula: C₃₉H₄₃N₃O₁₁S

InChI: InChI=1/C40H45N3O11S/c1-17-11-21-12-23-38(47)43-24-15-51-39(48)40(22-14-26(49-5)25(45)13-20(22)7-9-41-40)8-10-55-37(31(43)30(42(23)4)27(21)32(46)33(17)50-6)29-28(24)36-35(52-16-53-36)18(2)34(29)54-19(3)44/h11,13-14,23-24,30-31,37-38,41,45-47H,7-10,12,15-16H2,1-6H3/t23-,24-,30+,31+,37+,38-,40+/m0/s1

InChI key: InChIKey=PKVRCIRHQMSYJX-AIFWHQITSA-N

SMILES: O=C(OC=1C(=C2OCOC2=C3C1C4SCC5(NCCC6=CC(O)=C(OC)C=C65)C(=O)OCC3N7C(O)C8N(C)C(C9=C(O)C(OC)=C(C=C9C8)C)C74)C)C

Synonyms:

• (1'R,6R,6aR,7R,13S,14S,16R)-6',8,14-Trihydroxy-7',9-dimethoxy-4,10,23-trimethyl-19-oxo-3',4',6,7,12,13,14,16-octahydrospiro(6,16-(epithiopropanooxymethano)-7,13-imino-6aH-1,3-dioxolo(7,8)isoquino(3,2-b)(3)benzazocine-20,1'(2'H)-isoquinolin)-5-yl acetate
• (1′R,6R,6aR,7R,13S,14S,16R)-5-(Acetyloxy)-3′,4′,6,6a,7,13,14,16-octahydro-6′,8,14-trihydroxy-7′,9-dimethoxy-4,10,23-trimethylspiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1′(2′H)-isoquinolin]-19-one
• 1,3-Benzodioxole-5-propanoic acid,7-methyl-6-(phenylmethoxy)-α-[[(phenylmethoxy)carbonyl]amino]-,2,2-dimethoxyethyl ester
• Ccris 8133
• Ect 743
• Ecteinascidin
• Ecteinascidine 743
• Et-743
• Nsc 648766
• Spiro(6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo(7,8)isoquino(3,2,-b)(3)benzazocine-20,1'(2'H)-isoquinolin)-19-one, 3',4',6,6a,7,13,14,16-octahydro-5-(acetyloxy)-6',8,14-trihydroxy-7',9-dimethoxy-4,10,23-trimethyl-, (6R-(6-alpha,6a-beta,7-beta,13-beta,14-beta,16-alpha,20R*))-
• Spiro(6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo(7,8)isoquino(3,2,-b)(3)benzazocine-20,1'(2'H)-isoquinolin)-19-one, 5-(acetyloxy)-3',4',6,6a,7,13,14,16-octahydro-6',8,14-trihydroxy-7',9-dimethoxy-4,10,23-trimethyl-, (1'R,6R,6aR,7R,13S,14S,16R)-
• Spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1′(2′H)-isoquinolin]-19-one, 5-(acetyloxy)-3′,4′,6,6a,7,13,14,16-octahydro-6′,8,14-trihydroxy-7′,9-dimethoxy-4,10,23-trimethyl-, (1′R,6R,6aR,7R,13S,14S,16R)-
• Spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1′(2′H)-isoquinolin]-19-one, 5-(acetyloxy)-3′,4′,6,6a,7,13,14,16-octahydro-6′,8,14-trihydroxy-7′,9-dimethoxy-4,10,23-trimethyl-, [6R-(6α,6aβ,7β,13β,14β,16α,20R*)]-
• Trabectedin
• Unii-Id0Yzq2Tcp
• Yondelis
• ecteinascidin 743
• ecteinascidin 743,Trabectedin,ET 743
• Trabectedin Q: What is the storage condition of
• PKVRCIRHQMSYJX-ZKZLGIKISA-N
• (1'R,6R,6aR,7R,13S,14S,16R)-
• Trabectedin Q: What is the CAS Number of
• ASMF Filed
• NSC-684766
• ECTEINASCIDIN 743; ET-743; ECTEINASCIDIN
• Trabectedin (Ecteinascidin 743)
• Trabectedin Q: What are the applications of
• Trabectedin (Yondelis)
• Yondelis R ,Trabectedin
• TrabectedinQ: What is
• Trabectedin(Ecteinascidin 743,NSC-684766,ET-743)
• Trabectedin, >95%
• Trabectedin(Ecteinascidin 743,NSC-684766,ET-743, Yondelis)
• cteinascidin
• ET 743,Ecteinascidin743,inhibit,ROS,Inhibitor,Trabectedin,backbone,Ecteinascidin-743,Cytotoxicity,tetrahydroisoquinoline,superoxides,ET743,DNA,Apoptosis,alkaloid,cell-cycle,anti-inflammatory,antitumor,Reactive Oxygen Species

ecteinascidin 743

CAS: 114899-77-3

• Formula: C₃₉H₄₃N₃O₁₁S
• Purity: 99%
• Color and Shape: Solid
• Molecular weight: 761.8372

Trabectedin

CAS: 114899-77-3

• Purity: ≥98%
• Molecular weight: 761.84g/mol

Trabectedin

CAS: 114899-77-3

• Formula: C₃₉H₄₃N₃O₁₁S
• Molecular weight: 761.84

Trabectedin

CAS: 114899-77-3

Trabectedin (Ecteinascidin 743) has potent antitumor activity and the potential for soft tissue sarcoma and …

• Formula: C₃₉H₄₃N₃O₁₁S
• Purity: ≥98%
• Color and Shape: Solid
• Molecular weight: 761.84

Trabectedin

CAS: 114899-77-3

Applications A tetrahydroisoquinoline alkaloid with antitumor activity isolated from the Caribbean tunicate, Ecteinascidin turbinata. It …

• Formula: C₃₉H₄₃N₃O₁₁S
• Color and Shape: Neat
• Molecular weight: 761.84

Trabectedin

CAS: 114899-77-3

Trabectedin is a model system for investigating the role of protein genes in cancer. It …

• Formula: C₃₉H₄₃N₃O₁₁S
• Purity: Min. 95%
• Color and Shape: White/Off-White Solid
• Molecular weight: 761.84 g/mol