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CAS 114903-05-8

:

Fondaparinux sodium N-3

Description:
Fondaparinux sodium, with the CAS number 114903-05-8, is a synthetic anticoagulant that belongs to the class of drugs known as pentasaccharides. It is primarily used for the prevention and treatment of venous thromboembolism and is particularly effective in patients undergoing orthopedic or abdominal surgery. Fondaparinux works by selectively inhibiting factor Xa, an essential component in the coagulation cascade, thereby preventing the formation of blood clots. This compound is characterized by its high bioavailability and predictable pharmacokinetics, which allows for subcutaneous administration without the need for routine monitoring of coagulation parameters. Fondaparinux sodium is water-soluble and has a relatively low molecular weight, contributing to its favorable pharmacological profile. Additionally, it has a long half-life, which supports once-daily dosing. As with any anticoagulant, it is essential to monitor for potential bleeding complications and contraindications, particularly in patients with renal impairment or active bleeding disorders.
Formula:C81H91N7O27
InChI:InChI=1S/C81H91N7O27/c1-99-76-58(84-81(98)106-46-53-35-21-8-22-36-53)65(101-41-48-25-11-3-12-26-48)64(56(39-91)107-76)111-79-61(93)67(103-43-50-29-15-5-16-30-50)69(71(114-79)74(94)95)112-77-57(85-87-82)60(92)62(54(37-89)108-77)110-80-73(105-45-52-33-19-7-20-34-52)68(104-44-51-31-17-6-18-32-51)70(72(115-80)75(96)97)113-78-59(86-88-83)66(102-42-49-27-13-4-14-28-49)63(55(38-90)109-78)100-40-47-23-9-2-10-24-47/h2-36,54-73,76-80,89-93H,37-46H2,1H3,(H,84,98)(H,94,95)(H,96,97)/t54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68+,69+,70+,71-,72+,73-,76+,77-,78-,79-,80-/m1/s1
InChI key:InChIKey=YJFUPTPXBAYHGB-JFHRUGPCSA-N
SMILES:O([C@H]1[C@H](OCC2=CC=CC=C2)[C@@H](OCC3=CC=CC=C3)[C@H](O[C@@H]4[C@@H](CO)O[C@H](O[C@H]5[C@H](OCC6=CC=CC=C6)[C@@H](O)[C@H](O[C@H]7[C@H](OCC8=CC=CC=C8)[C@@H](NC(OCC9=CC=CC=C9)=O)[C@@H](OC)O[C@@H]7CO)O[C@H]5C(O)=O)[C@H](N=[N+]=[N-])[C@H]4O)O[C@@H]1C(O)=O)[C@@H]%10[C@H](N=[N+]=[N-])[C@@H](OCC%11=CC=CC=C%11)[C@H](OCC%12=CC=CC=C%12)[C@@H](CO)O%10
Synonyms:
  • Fondaparinux Sodium intermediate N-3
  • Methyl O-2-azido-2-deoxy-3,4-bis-O-(phenylmethyl)-α-<span class="text-smallcaps">D</smallcap>-glucopyranosyl-(1→4)-O-2,3-bis-O-(phenylmethyl)-β-<smallcap>D</smallcap>-glucopyranuronosyl-(1→4)-O-2-azido-2-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→4)-O-3-O-(phenylmethyl)-α-<smallcap>L</smallcap>-idopyranuronosyl-(1→4)-2-deoxy-2-[[(phenylmethoxy)carbonyl]amino]-3-O-(phenylmethyl)-α-<smallcap>D</span>-glucopyranoside
  • Methyl-O-(2-azido-3,4-di-O-benzyl-2-deoxy-a-D-glucopyranosyl)-(1-4)-O-(2,3-di-Obenzyl-β-D-glucopyranosyluronicacid)-(1-4)-O-(2-azido-2-deoxy-a-D-glucopyranosyl)-(1-4)-O-(3-O-benzyl-a-L-idopyranosyluronic acid)-(1-4)-3-O-benzyl-2-benzyloxycarbonylamino-2-deoxy-a-D-glucopyranoside
  • N-3 Intermediate, Fondaparinux
  • N-3 for Fondaparinux sodium
  • Pentasaccharide N-3 Intermediate
  • α-<span class="text-smallcaps">D</smallcap>-Glucopyranoside, methyl O-2-azido-2-deoxy-3,4-bis-O-(phenylmethyl)-α-<smallcap>D</smallcap>-glucopyranosyl-(1→4)-O-2,3-bis-O-(phenylmethyl)-β-<smallcap>D</smallcap>-glucopyranuronosyl-(1→4)-O-2-azido-2-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→4)-O-3-O-(phenylmethyl)-α-<smallcap>L</span>-idopyranuronosyl-(1→4)-2-deoxy-2-[[(phenylmethoxy)carbonyl]amino]-3-O-(phenylmethyl)-
  • Methyl O-2-azido-2-deoxy-3,4-bis-O-(phenylmethyl)-α-D-glucopyranosyl-(1→4)-O-2,3-bis-O-(phenylmethyl)-β-D-glucopyranuronosyl-(1→4)-O-2-azido-2-deoxy-α-D-glucopyranosyl-(1→4)-O-3-O-(phenylmethyl)-α-L-idopyranuronosyl-(1→4)-2-deoxy-2-[[(phenylmethoxy)carbonyl]amino]-3-O-(phenylmethyl)-α-D-glucopyranoside
  • α-D-Glucopyranoside, methyl O-2-azido-2-deoxy-3,4-bis-O-(phenylmethyl)-α-D-glucopyranosyl-(1→4)-O-2,3-bis-O-(phenylmethyl)-β-D-glucopyranuronosyl-(1→4)-O-2-azido-2-deoxy-α-D-glucopyranosyl-(1→4)-O-3-O-(phenylmethyl)-α-L-idopyranuronosyl-(1→4)-2-deoxy-2-[[(phenylmethoxy)carbonyl]amino]-3-O-(phenylmethyl)-
  • Methyl-O-(2-azido-3,4-di-O-benzyl-2-deoxy-a-D-glucopyranosyl)-(1-4)-O-(2,3-di-O-benzyl-b-D-glucopyranosyluronicacid)- (1-4)-O-(2-azido-2-deoxy-a-D-glucopyranosyl)-(1-4)-O-(3-O-benzyl-a-L-idopyranosyluronic acid)-(1-4)-3-O-benzyl- 2-benzyloxycarbonylamino-2-deoxy-a-D-glucopyranoside
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