CAS 114977-28-5

Taxotere

Description:

Taxotere, with the CAS number 114977-28-5, is a chemotherapeutic agent primarily used in the treatment of various cancers, including breast, lung, and prostate cancer. Its active ingredient is docetaxel, which is a semi-synthetic derivative of paclitaxel. Taxotere functions as a microtubule inhibitor, disrupting the normal function of the mitotic spindle during cell division, thereby inhibiting cancer cell proliferation. The substance is typically administered intravenously and is known for its effectiveness in combination with other chemotherapy agents. Taxotere is characterized by its solubility in organic solvents and its formulation often includes polysorbate 80 to enhance solubility in aqueous solutions. Common side effects associated with Taxotere include neutropenia, fatigue, nausea, and alopecia, among others. Due to its potent effects, it is classified as an antineoplastic agent and is subject to careful monitoring during treatment to manage potential adverse reactions.

Formula: C₄₃H₅₃NO₁₄

InChI: InChI=1/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52)/t26-,27-,28+,30-,31+,32+,33-,35-,41-,42-,43+/m0/s1

InChI key: InChIKey=ZDZOTLJHXYCWBA-VCVYQWHSSA-N

SMILES: O(C(C)=O)[C@]12[C@]3([C@H](OC(=O)C4=CC=CC=C4)[C@@]5(O)C(C)(C)C([C@@H](O)C(=O)[C@]3(C)[C@@H](O)C[C@]1(OC2)[H])=C(C)[C@@H](OC([C@@H]([C@@H](NC(OC(C)(C)C)=O)C6=CC=CC=C6)O)=O)C5)[H]

Synonyms:

• (1beta,2alpha,5beta,7beta,10beta,13alpha)-4-(acetyloxy)-13-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
• (2alpha,5beta,7beta,10beta,13alpha)-4-(acetyloxy)-13-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
• (2alpha,5beta,7beta,10beta,13alpha)-4-(acetyloxy)-13-({(3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
• 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
• Ati 1123
• Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
• Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, 12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-
• Bind-014
• Ckd 810
• Crlx 301
• Decetaxel anhydrous
• Docefrez
• Docetaxel
• Docetaxel Anhydrous
• Docetaxol
• Docetere
• Duopafei
• Miradocetaxel
• N-Debenzoyl-N-tert-butoxycarbonyl-10-deacetyltaxol
• N-debenzoyl-N-tert-butoxycarbonyl-10-deacetyl taxol
• Rp 56976
• Sid 530
• Taxotel
• docetaxcel，DTX
• )benz(1,2-b)oxet-9-ylester,(2ar-(2a-alpha,4-beta,4a-beta,6-beta,9-alpha(alph
• TAXOTERE
• DOCETAXEL (TAXOTERE)
• Docetaxel9.5%
• Benzenepropanoic acid, b-[[(1,1-dimethylethoxy)carbonyl]amino]-a-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trih
• Docetaxel99.5%
• DOCETAXEL TRIHYDRATE
• DocetaxelAnhydrous/Trihydrate
• beta-s*),11-alpha,12-alpha,12a-alpha,12b-alpha))-a-r
• n-debenzoyl-n-(tert-butoxycarbonyl)taxol
• o-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1h-cyclodeca(3,4
• rp56976
• DocetaxelAnhydrousin-HouseStandard
• benzenepropanoicacid,beta-(((1,1-dimethylethoxy)carbonyl)amino)-alpha-hydroxy
• DOCETAXEL ANHYDROUS 99.5%
• -,12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydr

Docetaxel

CAS: 114977-28-5

Formula: C₄₃H₅₃NO₁₄

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 807.89

Ref: 3B-D4102

Docetaxel, 99%

CAS: 114977-28-5

Docetaxel, 114977-28-5, is a taxoid antineoplastic agent and a second-generation cytotoxic antimicrotubule agent. Learn more at Thermo Fisher Scientific.

Formula: C₄₃H₅₃NO₁₄

Purity: 99%

Molecular weight: 807.89

Ref: 02-J60174

ANHYDROUS DOCETAXEL CRS

CAS: 114977-28-5

ANHYDROUS DOCETAXEL CRS

Formula: C₄₃H₅₃NO₁₄

Color and Shape: Crystalline Powder. White. Powder.

Molecular weight: 807.8792

Ref: 41-Y0001466

Docetaxel

CAS: 114977-28-5

Docetaxel (RP-56976) is a semi-synthetic analog of paclitaxel, a microtubule depolymerization inhibitor (IC50=0.2 μM).

Formula: C₄₃H₅₃NO₁₄

Purity: 98.6% - 99.29%

Color and Shape: Off-White Cryst

Molecular weight: 807.88

Ref: TM-T1034

Docetaxel

CAS: 114977-28-5

Formula: C₄₃H₅₃NO₁₄

Purity: %

Color and Shape: Solid

Molecular weight: 807.8792

Ref: IN-DA0039I1

Docetaxel

CAS: 114977-28-5

Formula: C₄₃H₅₃NO₁₄·xH₂O

Purity: ≤ 0.1%

Color and Shape: White to off-white crystalline powder

Molecular weight: 807.88 (anhydrous)

Ref: 7W-GP5102

Docetaxel

CAS: 114977-28-5

Docetaxel

Formula: C₄₃H₅₃NO₁₄

Purity: >99%

Color and Shape: white crystalline solid or powder

Molecular weight: 807.87922g/mol

Ref: 54-BID2710

Docetaxel

CAS: 114977-28-5

Formula: C₄₃H₅₃NO₁₄

Color and Shape: White To Off-White Solid

Molecular weight: 807.89

Ref: 4Z-D-191

Docetaxel Anhydrous

Controlled Product

CAS: 114977-28-5

Formula: C₄₃H₅₃NO₁₄

Color and Shape: Neat

Molecular weight: 807.88

Ref: 86-MM3390.00

Docetaxel

CAS: 114977-28-5

Docetaxel is an antineoplastic drug by inhibiting microtubule depolymerization, and attenuating of the effects of bcl-2 and bcl-xL gene expression.

Formula: C₄₃H₅₃NO₁₄

Purity: 95%~99%

Molecular weight: 807.89

Ref: BP-BP0514

Docetaxel

CAS: 114977-28-5

Applications Docetaxel is an antimitotic Taxol analog antibiotic.

Formula: C₄₃H₅₃NO₁₄

Color and Shape: Off White Solid

Molecular weight: 807.88

Ref: TR-D525623

Docetaxel

CAS: 114977-28-5

A cytotoxic taxane and anti-microtubule agent with anti-proliferative activity. Docetaxel binds to the β-subunit of tubulin, which results in increased polymerisation and stabilisation of microtubules. The compound interferes with microtubule dynamics, which leads to the cell cycle arrest in the G2/M phase and apoptosis. The compound has significant inhibitory activity in solid tumors either alone or in combination with other chemotherapeutic agents.

Formula: C₄₃H₅₃NO₁₄

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 807.88 g/mol

Ref: 3D-FD10817

Docetaxel - Bio-X ™

CAS: 114977-28-5

Docetaxel is an antineoplastic agent that is used to treat various cancers such as breast and prostate cancer. This drug interferes with the normal function of microtubule growth. It is an anti-mitotic drug used in chemotherapy. Research has shown that this drug also induces programmed cell death in cancer cells.

Formula: C₄₃H₅₃NO₁₄

Purity: Min. 90 Area-%

Color and Shape: White/Off-White Solid

Molecular weight: 807.88 g/mol

Ref: 3D-BD164373

Docetaxel Anhydrous

CAS: 114977-28-5

Color and Shape: Neat

Ref: 61-FOR3390.00