CAS 114991-26-3

PROPOFOL GLUCURONIDE

Description:

Propofol glucuronide is a metabolite of propofol, an intravenous anesthetic widely used for sedation and anesthesia. This compound is formed through the glucuronidation process, where propofol undergoes conjugation with glucuronic acid, enhancing its solubility and facilitating excretion. Propofol glucuronide is characterized by its relatively high polarity compared to its parent compound, which affects its pharmacokinetics and pharmacodynamics. It is typically found in biological fluids, such as urine, following the administration of propofol. The substance is not pharmacologically active like propofol, but its presence is significant for understanding the drug's metabolism and clearance from the body. The chemical structure includes a phenolic hydroxyl group, which is essential for the glucuronidation reaction. Propofol glucuronide is important in clinical settings for monitoring drug metabolism and potential drug interactions, as well as in toxicology studies to assess exposure levels in patients receiving propofol.

Formula: C₁₈H₂₆O₇

Synonyms:

• Propofol-D-glucuronide

(2S,3S,4S,5R,6S)-6-(2,6-Diisopropylphenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid

CAS: 114991-26-3

Formula: C₁₈H₂₆O₇

Purity: 99%

Color and Shape: Solid

Molecular weight: 354.3948

Ref: IN-DA000FJA

Propofol-D-glucuronide

CAS: 114991-26-3

Formula: C₁₈H₂₆O₇

Purity: ≥ 98.0%

Color and Shape: White to light yellow powder

Molecular weight: 354.39

Ref: 7W-GC8137

Propofol O-Glucuronide

CAS: 114991-26-3

Formula: C₁₈H₂₆O₇

Color and Shape: White To Off-White Solid

Molecular weight: 354.40

Ref: 4Z-P-292

Propofol β-D-Glucuronide

CAS: 114991-26-3

Propofol β-D-Glucuronide is the major inactive metabolite of isoproterenol sulfat, mediated by UGT, and can be used to study sleep deprivation (SD).

Formula: C₁₈H₂₆O₇

Color and Shape: Solid

Molecular weight: 354.4

Ref: TM-T37378

Propofol β-D-glucuronide

Controlled Product

CAS: 114991-26-3

Stability Hygroscopic
Applications Propofol β-D-Glucuronide is a metabolite of Propofol (P829750), an anesthetic used in veterinary medicine.
References Fujiwara, R., et al.: Drug Metab. Dispos., 35, 747 (2007), Soars, M., et al.: J. Pharmacol. Toxicol. Methods, 47, 161 (2002),

Formula: C₁₈H₂₆O₇

Color and Shape: White To Off-White

Molecular weight: 354.39

Ref: TR-P829780

Propofol-b-D-glucuronide

Controlled Product

CAS: 114991-26-3

Propofol-b-D-glucuronide is an inactive form of propofol that is metabolized by the liver to the active form. It is excreted in urine as its glucuronide conjugate. Propofol-b-D-glucuronide is used to help maintain a patient's anesthesia during surgery and has been shown to be effective in women, although it may cause drug interactions with other drugs. This drug also has a matrix effect on analytical methods, which means that the results are affected by the chemical composition of the sample preparation. The hydrolysis of propofol-b-D-glucuronide can be monitored using preparative high performance liquid chromatography (HPLC). The HPLC assay for propofol can be used to monitor uptake in humans and animals because it does not require radioactive substances or multiple injections of labeled propofol. Propofol-b-D-glucuronide also inhibits

Formula: C₁₈H₂₆O₇

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 354.39 g/mol

Ref: 3D-MP07301

Propofol O-Glucuronide

CAS: 114991-26-3

Formula: C₁₈H₂₆O₇

Molecular weight: 354.40

Ref: ST-EA-CP-P4029