CAS 114991-28-5
:HIV (gp120) Fragment (315-329)
Description:
The chemical substance known as "HIV (gp120) Fragment (315-329)" with the CAS number 114991-28-5 is a peptide fragment derived from the envelope glycoprotein gp120 of the Human Immunodeficiency Virus (HIV). This fragment is significant in immunological research and vaccine development due to its role in the virus's ability to bind to CD4 receptors on host cells, facilitating viral entry. The peptide consists of a specific sequence of amino acids that are crucial for the structural and functional properties of the gp120 protein. It is often used in studies aimed at understanding HIV pathogenesis and in the design of therapeutic agents or vaccines that can elicit an immune response. The fragment may also be utilized in assays to evaluate antibody responses in infected individuals or vaccine recipients. As a synthetic or recombinant peptide, it is typically characterized by its purity, solubility, and stability under various conditions, which are essential for its application in research and clinical settings.
Formula:C73H126N26O18
Synonyms:- H-Arg-Ile-Gln-Arg-Gly-Pro-Gly-Arg-Ala-Phe-Val-Thr-Ile-Gly-Lys-OH
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 2 products.
HIV-1 env Protein gp120 (278-292) (strains BH10, BH8, HXB2, HXB3, PV22)
CAS:<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>Formula:C73H126N26O18Molecular weight:1,656 g/molHIV-1 env Protein gp120 (278-292) (strains BH10, BH8, HXB2, HXB3, PV22)
CAS:<p>The HIV-1 envelope protein, gp120, is a transmembrane glycoprotein that plays a key role in the viral entry process. The gp120 protein contains the binding site for the CD4 receptor and can be cleaved by proteases to remove the membrane-spanning domain. The resulting soluble gp120 (sgp120) is an important co-receptor for HIV infection of target cells such as prostate cancer cells. The sgp120 binds to heparin sulfate proteoglycans on the surface of target cells and triggers cellular activation pathways including angiogenic factors, which induce cell proliferation and migration. This process is important for tumour growth and metastasis, inflammatory bowel disease, and other inflammatory diseases. The sgp120 has also been shown to activate pro-apoptotic proteins such as Bcl-2 family members and Bax. These proteins play a crucial role in apoptosis pathway by regulating mitochondrial membrane integrity, cytochrome c release from mitochond</p>Formula:C73H126N26O18Purity:Min. 95%Molecular weight:1,655.95 g/mol
