CAS 115-02-6: Azaserine

Description: Azaserine is a synthetic compound classified as an antibiotic and an antimetabolite, primarily known for its role in cancer research and as a tool in biochemical studies. It is a pyrimidine analog that inhibits the enzyme glutamine amidotransferase, which is crucial in nucleotide synthesis, thereby interfering with DNA and RNA synthesis. This mechanism makes azaserine particularly valuable in studying cellular processes and the effects of nucleotide depletion. The compound is typically a white to off-white crystalline solid, soluble in water and various organic solvents. Azaserine has been utilized in laboratory settings to explore its effects on cell growth and differentiation, especially in relation to tumor cells. However, due to its potent biological activity, it must be handled with care, as it can exhibit cytotoxic effects. Its use is primarily restricted to research applications, and it is not approved for therapeutic use in humans. Overall, azaserine serves as an important compound in the field of cancer research and biochemistry.

Formula: C₅H₇N₃O₄

InChI: InChI=1S/C5H7N3O4/c6-3(5(10)11)2-12-4(9)1-8-7/h1,3H,2,6H2,(H,10,11)/t3-/m0/s1

InChI key: InChIKey=MZZGOOYMKKIOOX-VKHMYHEASA-N

SMILES: [N-]=[N+]=CC(=O)OCC(N)C(=O)O

Synonyms:

• (2S)-2-Amino-3-[(2-diazoacetyl)oxy]propanoic acid
• (E)-1-(2-amino-2-carboxyethoxy)-2-diazonioethenolate
• (E)-1-[(2S)-2-amino-2-carboxyethoxy]-2-diazonioethenolate
• (S)-2-Amino-3-(2-diazoacetoxy)propanoic acid
• 1-(2-Amino-2-Carboxyethoxy)-2-Diazonioethenolate
• <span class="text-smallcaps">L</span>-Azaserine
• <span class="text-smallcaps">L</span>-Serine, O-(2-diazoacetyl)-
• <span class="text-smallcaps">L</span>-Serine, diazoacetate (ester)
• Azaserin
• Ci 337
• Cn 15757
• NSC 742
• O-(2-Diazoacetyl)-<span class="text-smallcaps">L</span>-serine
• O-(diazen-1-iumylideneacetyl)serine
• O-(diazoacetyl)serine
• O-Diazoacetyl-<span class="text-smallcaps">L</span>-serine
• P 165
• Serine, diazoacetate (ester), <span class="text-smallcaps">L</span>-

L-Serine, O-(2-diazoacetyl)-

CAS: 115-02-6

• Formula: C₅H₇N₃O₄
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 173.1268

Azaserine

CAS: 115-02-6

• Formula: C₅H₇N₃O₄
• Molecular weight: 173.13

(2S)-2-amino-3-[(2-diazoacetyl)oxy]propanoic acid

CAS: 115-02-6

• Purity: 98+%
• Molecular weight: 173.1280059814453

Azaserine

CAS: 115-02-6

Glutamine analogue and antagonist of glutamine-dependent amidotransferases, with antibiotic and antifungal properties. Inhibits purine biosynthesis, …

• Formula: C₅H₇N₃O₄
• Purity: Min. 98 Area-%
• Color and Shape: Slightly Yellow Powder
• Molecular weight: 173.13 g/mol

Azaserine

CAS: 115-02-6

Azaserine (CI-337) is a tumor-inhibiting antibiotic isolated from a species of Streptomyces and functions as …

• Formula: C₅H₇N₃O₄
• Purity: 98% - 99.84%
• Color and Shape: Solid
• Molecular weight: 173.13

Azaserine

CAS: 115-02-6

• Formula: C₅H₇N₃O₄
• Color and Shape: Neat
• Molecular weight: 173.127