CAS 115-79-7

ambenonium chloride

Description:

Ambenonium chloride is a synthetic chemical compound classified as a quaternary ammonium salt. It is primarily recognized for its role as a reversible inhibitor of the enzyme acetylcholinesterase, which leads to increased levels of acetylcholine in the synaptic cleft, enhancing neuromuscular transmission. This property makes it useful in the treatment of certain neuromuscular disorders, such as myasthenia gravis. The compound appears as a white to off-white crystalline powder and is soluble in water, which facilitates its administration in clinical settings. Its chemical structure includes a central nitrogen atom bonded to four organic groups, contributing to its quaternary nature. Ambenonium chloride is typically administered orally or via injection, and its pharmacological effects can lead to side effects such as gastrointestinal disturbances and muscle cramps. As with many medications, careful dosage and monitoring are essential to minimize adverse reactions and ensure therapeutic efficacy. Proper handling and storage conditions are also important to maintain its stability and effectiveness.

Formula: C₂₈H₄₂Cl₂N₄O₂·2Cl

InChI: InChI=1/C28H40Cl2N4O2.2ClH/c1-5-33(6-2,21-23-13-9-11-15-25(23)29)19-17-31-27(35)28(36)32-18-20-34(7-3,8-4)22-24-14-10-12-16-26(24)30;;/h9-16H,5-8,17-22H2,1-4H3;2*1H

InChI key: InChIKey=DXUUXWKFVDVHIK-UHFFFAOYSA-N

SMILES: [N+](CC1=C(Cl)C=CC=C1)(CCNC(C(NCC[N+](CC2=C(Cl)C=CC=C2)(CC)CC)=O)=O)(CC)CC.[Cl-]

Synonyms:

• 2,2'-[(1,2-dioxoethane-1,2-diyl)diimino]bis[N-(2-chlorobenzyl)-N,N-diethylethanaminium] dichloride
• Ambenonium dichloride
• Ambestigmin chloride
• Ammonium, [oxalylbis(iminoethylene)]bis[(o-chlorobenzyl)diethyl-, dichloride
• Benzenemethanaminium, N,N′-[(1,2-dioxo-1,2-ethanediyl)bis(imino-2,1-ethanediyl)]bis[2-chloro-N,N-diethyl-, chloride (1:2)
• Benzenemethanaminium, N,N′-[(1,2-dioxo-1,2-ethanediyl)bis(imino-2,1-ethanediyl)]bis[2-chloro-N,N-diethyl-, dichloride
• Misuran
• Mysuran
• Mysuran chloride
• Mytelase
• Mytelase chloride
• N,N-oxalylbis(2-aminoethyl-N-o-chlorobenzyldiethylammonium) dichloride
• N,N′-Bis-(2-diethylaminoethyl)oxamide bis-2-chlorobenzylchloride
• N,N′-Bis-2-[(2-chlorobenzyl)diethylammonium chloride]-ethyloxamide
• Oxamizil
• Oxazil
• Oxazyl
• Win 8077
• [Oxalylbis(iminoethylene)]bis[(o-chlorobenzyl)diethylammonium chloride]
• Ambestigmin
• ambenonium chloride
• ambenonium chloride USP/EP/BP
• (2-chlorophenyl)methyl-[2-[[2-[2-[(2-chlorophenyl)methyl-diethyl-azaniumyl]ethylamino]-2-oxo-ethanoyl]amino]ethyl]-diethyl-azanium dichloride
• (2-chlorophenyl)methyl-[2-[[2-[2-[(2-chlorophenyl)methyl-diethylazaniumyl]ethylamino]-2-oxoacetyl]amino]ethyl]-diethylazanium dichloride

Ambenonium Dichloride

CAS: 115-79-7

Formula: C₂₈H₄₂Cl₂N₄O₂·2Cl

Molecular weight: 537.57 2*35.45

Ref: 4Z-A-412001

Ambenonium Dichloride

Controlled Product

CAS: 115-79-7

Applications Ambenonium Dichloride used in the discovery and design of ApoE4 (apolipoprotein E4) inhibitors with biological activity showing against Alzheimer’s disease. Cholinesterase inhibitor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Dhanachandra S. et al.: Med. Chem. Res., 21, 825 (2012); Papp, M. et al.: Neurobio. Aging, 27, 402 (2006);

Formula: C₂₈H₄₂Cl₂N₄O₂·2Cl

Color and Shape: Off White Solid

Molecular weight: 608.47

Ref: TR-A575875

Ambenonium dichloride

CAS: 115-79-7

AChE inhibitor

Formula: C₂₈H₄₂Cl₃N₄O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 573.02

Ref: TM-T22564

Ambenonium Chloride

CAS: 115-79-7

Color and Shape: Neat

Ref: 61-FOR1782.00