CAS 115005-78-2

4-Hydroxy Propofol 4-O-b-D-Glucuronide

Description:

4-Hydroxy Propofol 4-O-b-D-Glucuronide is a metabolite of the widely used anesthetic agent propofol. This compound is characterized by the presence of a hydroxy group and a glucuronide moiety, which is a common conjugation that enhances the solubility and excretion of drugs in the body. The glucuronidation process typically occurs in the liver and is a key phase II metabolic pathway that facilitates the elimination of lipophilic substances. As a result, 4-Hydroxy Propofol 4-O-b-D-Glucuronide is more water-soluble than its parent compound, propofol, which aids in renal excretion. This metabolite may also play a role in the pharmacokinetics and pharmacodynamics of propofol, influencing its duration of action and potential side effects. The compound's structure includes a phenolic hydroxyl group, contributing to its chemical reactivity and interaction with biological systems. Understanding the characteristics of this metabolite is essential for comprehending the overall metabolism and safety profile of propofol in clinical settings.

Formula: C₁₈H₂₆O₈

InChI: InChI=1/C18H26O8/c1-7(2)10-5-9(6-11(8(3)4)12(10)19)25-18-15(22)13(20)14(21)16(26-18)17(23)24/h5-8,13-16,18-22H,1-4H3,(H,23,24)/t13-,14-,15-,16?,18+/m1/s1

Synonyms:

• 4-Hydroxy-3,5-bis(1-methylethyl)phenyl b-D-Glucopyranosiduronic Acid
• 4-Hydroxy Propofol 4-O--D-Glucuronide
• 4-Hydroxy-3,5-bis(1-methylethyl)phenyl -D-Glucopyranosiduronic Acid

4-Hydroxy Propofol 4-O-b-D-Glucuronide

CAS: 115005-78-2

Formula: C₁₈H₂₆O₈

Color and Shape: Solid

Molecular weight: 370.3942

Ref: IN-DA000FL6

4-Hydroxypropofol-4-O-b-D-glucuronide

CAS: 115005-78-2

Ref: 7W-GC7905

Propofol Impurity 30

CAS: 115005-78-2

Formula: C₁₈H₂₆O₈

Molecular weight: 370.40

Ref: 4Z-P-2954

4-Hydroxy Propofol 4-O-β-D-Glucuronide

Controlled Product

CAS: 115005-78-2

Stability Hygroscopic
Applications A metabolite of Propofol. Anesthetic (intravenous).
References Davies, M., et al.: Biochem. J., 257, 603 (1989), Eriksson, O., et al.: Biochem. Pharmacol., 44, 391 (1992), Bryson, H., et al.: Drugs, 50, 513, (1995), Raoof, A., et al.: Eur. J. Clin. Pharmacol., 50, 91 (1996)

Formula: C₁₈H₂₆O₈

Color and Shape: Neat

Molecular weight: 370.39

Ref: TR-H950780

4-Hydroxypropofol-4-O-b-D-glucuronide

CAS: 115005-78-2

4-Hydroxypropofol-4-O-b-D-glucuronide (HPG) is a synthetic carbohydrate with a 4,5-dihydroxypropyl group at C2 and an O-glycosidic bond between the hydroxyl group at C1 and the b position of a glucuronic acid. HPG is used in the synthesis of complex carbohydrates and saccharides. It can be methylated in order to produce 5,6-dimethoxycarbonyloxypropyl glycosides or glycosylated to produce mannosides. HPG has been synthesized by click modification from 4,5-dihydroxypropionic acid.

Formula: C₁₈H₂₆O₈

Purity: Min. 95%

Molecular weight: 370.4 g/mol

Ref: 3D-MH09761