CAS 115044-69-4

CALMODULIN-DEPENDENT PROTEIN KINASE II (290-309)

Description:

Calmodulin-dependent protein kinase II (CaMKII) is a multifunctional enzyme that plays a crucial role in various cellular processes, particularly in the regulation of calcium signaling pathways. The specific fragment referred to as "CALMODULIN-DEPENDENT PROTEIN KINASE II (290-309)" likely pertains to a peptide sequence within the larger CaMKII protein, which is involved in the phosphorylation of target proteins in response to calcium and calmodulin binding. This kinase is known for its role in synaptic plasticity, learning, and memory in neurons. The CAS number 115044-69-4 identifies a specific chemical substance, which may refer to a synthetic or modified version of this peptide or a related compound. Characteristics of such substances typically include their molecular weight, solubility in various solvents, stability under physiological conditions, and their interaction with calmodulin and other cellular components. Understanding these characteristics is essential for exploring their potential applications in research and therapeutic contexts, particularly in neurobiology and cellular signaling.

Formula: C₁₀₃H₁₈₅N₃₁O₂₄S

Synonyms:

• Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala
• Lkkfnarrklkgailttmla
• Ca2+/Calmodulin-Dependent Protein Kinase Ii (290-309)
• Calmodulin Dependent Protein Kinase Ii
• Calmodulin Binding Domain
• Calmodulin-Dependent Protein Kinase Ii Fragment 290-309
• Cam Kinase Ii (290-309)

L-Alanine, L-leucyl-L-lysyl-L-lysyl-L-phenylalanyl-L-asparaginyl-L-alanyl-L-arginyl-L-arginyl-L-lysyl-L-leucyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-leucyl-L-threonyl-L-threonyl-L-methionyl-L-leucyl-

CAS: 115044-69-4

Formula: C₁₀₃H₁₈₅N₃₁O₂₄S

Molecular weight: 2273.8293

Ref: IN-DA000FR5

Calmodulin-dependent Protein Kinase II fragment 290-309

CAS: 115044-69-4

Formula: C₁₀₃H₁₈₅N₃₁O₂₄S

Molecular weight: 2273.83

Ref: 7W-GK7214

Calmodulin-Dependent Protein Kinase II (290-309)

CAS: 115044-69-4

Calmodulin-Dependent Protein Kinase II (290-309) is a potent CaMK antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II

Formula: C₁₀₃H₁₈₅N₃₁O₂₄S

Purity: 98%

Color and Shape: Solid

Molecular weight: 2273.83

Ref: TM-TP1271

Calmodulin-Dependent Protein Kinase II (290-309)

CAS: 115044-69-4

Calmodulin-dependent protein kinase II (CAMKII) is a calcium/calmodulin-dependent enzyme that plays an important role in the regulation of cardiac contractility. CAMKII is activated by the binding of beta-adrenergic and other hormones to their receptors on the plasma membrane, leading to a change in the membrane potential. CAMKII then phosphorylates myofibrils, which leads to an increase in cardiac contractility. In liver cells, CAMKII activation leads to an increase in contractility and perfusion through increased ethylene production.

Formula: C₁₀₃H₁₈₅N₃₁O₂₄S

Purity: Min. 95%

Molecular weight: 2,273.83 g/mol

Ref: 3D-FC110422