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CAS 115103-54-3

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Tiagabine

Description:
Tiagabine is a pharmaceutical compound primarily used as an anticonvulsant in the treatment of epilepsy. It functions as a selective inhibitor of the neurotransmitter gamma-aminobutyric acid (GABA) reuptake, thereby increasing GABA levels in the synaptic cleft and enhancing inhibitory neurotransmission. This mechanism contributes to its effectiveness in controlling seizures. Tiagabine is typically administered orally and is known for its relatively high bioavailability. The substance is characterized by its molecular formula, which includes carbon, hydrogen, nitrogen, and oxygen atoms, reflecting its organic nature. It is generally well-tolerated, although potential side effects may include dizziness, fatigue, and cognitive disturbances. Tiagabine's pharmacokinetics involve hepatic metabolism, primarily through cytochrome P450 enzymes, and it has a moderate half-life, necessitating multiple daily doses for sustained therapeutic effects. As with any medication, it is essential for patients to follow prescribed dosages and consult healthcare professionals regarding potential interactions and contraindications.
Formula:C20H25NO2S2
InChI:InChI=1S/C20H25NO2S2/c1-14-7-11-24-18(14)17(19-15(2)8-12-25-19)6-4-10-21-9-3-5-16(13-21)20(22)23/h6-8,11-12,16H,3-5,9-10,13H2,1-2H3,(H,22,23)/t16-/m1/s1
InChI key:InChIKey=PBJUNZJWGZTSKL-MRXNPFEDSA-N
SMILES:C(=CCCN1C[C@H](C(O)=O)CCC1)(C2=C(C)C=CS2)C3=C(C)C=CS3
Synonyms:
  • (3R)-1-[4,4-Bis(3-methyl-2-thienyl)-3-buten-1-yl]-3-piperidinecarboxylic acid
  • (3R)-1-[4,4-bis(3-methylthiophen-2-yl)but-3-en-1-yl]piperidine-3-carboxylic acid
  • (R)-Tiagabine
  • 1-[4,4-Bis(3-Methylthiophen-2-Yl)But-3-En-1-Yl]Piperidine-3-Carboxylic Acid
  • 3-Piperidinecarboxylic acid, 1-[4,4-bis(3-methyl-2-thienyl)-3-buten-1-yl]-, (3R)-
  • 3-Piperidinecarboxylic acid, 1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-, (3R)-
  • 3-Piperidinecarboxylic acid, 1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-, (R)-
  • Gabatril
  • No 050328
  • No 328
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