CAS 115279-73-7

1-(4-Aminophenyl)cyclopentanecarbonitrile

Description:

1-(4-Aminophenyl)cyclopentanecarbonitrile, identified by its CAS number 115279-73-7, is an organic compound characterized by the presence of a cyclopentane ring substituted with a carbonitrile group and an amino group attached to a phenyl ring. This compound typically exhibits properties associated with both aromatic and aliphatic systems, including potential solubility in organic solvents and moderate polarity due to the presence of the amino and nitrile functional groups. The amino group can participate in hydrogen bonding, influencing its reactivity and interactions with other molecules. Additionally, the carbonitrile group contributes to the compound's overall stability and can serve as a site for further chemical modifications. The compound may be of interest in medicinal chemistry and material science due to its structural features, which could impart unique biological activities or physical properties. As with many organic compounds, safety and handling precautions should be observed, particularly regarding potential toxicity associated with the amino group.

Formula: C₁₂H₁₄N₂

InChI: InChI=1/C12H14N2/c13-9-12(7-1-2-8-12)10-3-5-11(14)6-4-10/h3-6H,1-2,7-8,14H2

SMILES: C1CCC(C1)(C#N)c1ccc(cc1)N

Synonyms:

• Cyclopentanecarbonitrile, 1-(4-aminophenyl)-
• 1-(4-aminophenyl)-Cyclopentanecarbonitrile
• 1-(4-aminophenyl)cyclopentane-1-carbonitrile

Cyclopentanecarbonitrile, 1-(4-aminophenyl)-

CAS: 115279-73-7

Formula: C₁₂H₁₄N₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 186.2530

Ref: IN-DA000GJR

1-(4-Aminophenyl)cyclopentanecarbonitrile

CAS: 115279-73-7

1-(4-Aminophenyl)cyclopentanecarbonitrile

Purity: 98%

Molecular weight: 186.25g/mol

Ref: 54-OR952958

1-(4-Aminophenyl)cyclopentanecarbonitrile

CAS: 115279-73-7

Formula: C₁₂H₁₄N₂

Purity: 98%

Color and Shape: Liquid, No data available.

Molecular weight: 186.258

Ref: 10-F209992

1-(4-Aminophenyl)cyclopentanecarbonitrile

Controlled Product

CAS: 115279-73-7

Formula: C₁₂H₁₄N₂

Color and Shape: Neat

Molecular weight: 186.253

Ref: TR-A615550

1-(4-Aminophenyl)cyclopentanecarbonitrile-d8

Controlled Product

CAS: 115279-73-7

Applications 1-(4-Aminophenyl)cyclopentanecarbonitrile-d8 is an intermediate used in the synthesis of Apatinib-d8 Hydrochloride (A726152), which is a labelled Apatinib (A726150). Apatinib is an orally available, small molecule multitargeted tyrosine kinase inhibitor. Apatinib selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2). Apatinib functions by inhibiting VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. Recent studies have shown that Apatinib enhances the efficacy of conventional chemotherapeutical drugs in side population (SP) cells and ABCB1-overexpressing leukemia cells.
References Mi, Y. et al.: Cancer Res., 70, 7981 (2010); Tong, X.Z. et al.: Biochem. Pharmacol., 83, 586 (2012); Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);

Formula: C₁₂D₈H₆N₂

Color and Shape: Neat

Molecular weight: 194.302

Ref: TR-A615552