CAS 1154-25-2

EIPA

Description:

EIPA, or 5-ethyl-2-(4-(1-pyrrolidinyl)butyl)-1H-imidazole, is a chemical compound characterized by its imidazole structure, which is a five-membered ring containing two nitrogen atoms. It is primarily recognized for its role as a selective inhibitor of the Na+/H+ exchanger, making it significant in various biological and pharmacological studies. EIPA is often utilized in research to investigate cellular processes related to ion transport and pH regulation. The compound is typically a white to off-white solid and is soluble in organic solvents, which facilitates its use in laboratory settings. Its molecular interactions and effects on cellular mechanisms have made it a valuable tool in studies related to cardiovascular health, cancer research, and cellular signaling pathways. As with many chemical substances, proper handling and safety precautions are essential due to potential toxicity and reactivity.

Formula: C₁₁H₁₈ClN₇O

InChI: InChI=1S/C11H18ClN7O/c1-4-19(5(2)3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20)

InChI key: InChIKey=QDERNBXNXJCIQK-UHFFFAOYSA-N

SMILES: N(C(C)C)(CC)C=1C(Cl)=NC(C(NC(=N)N)=O)=C(N)N1

Synonyms:

• 2-Pyrazinecarboxamide, 3-amino-N-(aminoiminomethyl)-6-chloro-5-[ethyl(1-methylethyl)amino]-
• 3-Amino-N-(aminoiminomethyl)-6-chloro-5-[ethyl(1-methylethyl)amino]-2-pyrazinecarboxamide
• 3-amino-6-chloro-N-(diaminomethylidene)-5-[ethyl(propan-2-yl)amino]pyrazine-2-carboxamide
• Ethylisopropylamiloride
• L 593754
• Mh 12-43
• Pyrazinecarboxamide, 3-amino-N-(aminoiminomethyl)-6-chloro-5-[ethyl(1-methylethyl)amino]-
• Pyrazinecarboxamide, N-amidino-3-amino-6-chloro-5-(ethylisopropylamino)-
• 5-(N-Ethyl-N-Isopropyl) Amiloride
• 5-(N-Ethyl-N-isopropyl)amiloride

2-Pyrazinecarboxamide, 3-amino-N-(aminoiminomethyl)-6-chloro-5-[ethyl(1-methylethyl)amino]-

CAS: 1154-25-2

Formula: C₁₁H₁₈ClN₇O

Purity: 95%

Color and Shape: Solid

Molecular weight: 299.7599

Ref: IN-DA000FXV

5-(N-Ethyl-N-isopropyl) amiloride

CAS: 1154-25-2

Formula: C₁₁H₁₈ClN₇O

Molecular weight: 299.76

Ref: 7W-GN3365

EIPA

CAS: 1154-25-2

EIPA

Purity: ≥95%

Molecular weight: 299.76g/mol

Ref: 54-BUP17571

EIPA

CAS: 1154-25-2

EIPA (L593754) is a TRPP3 channel inhibitor and an inhibitor of Na+/H+ exchange (NHE). EIPA inhibits megacytosis, promotes autophagy. Cost-effective and quality-assured.

Formula: C₁₁H₁₈ClN₇O

Purity: 96.62% - 99.981%

Color and Shape: Off-White To Yellow Solid

Molecular weight: 299.76

Ref: TM-TQ0157

5-(N-Ethyl-N-isopropyl) Amiloride

Controlled Product

CAS: 1154-25-2

Stability Unstable in methanol
Applications Selective Na+/H+ antiporter inhibitor. Selectively enhances the excretion of sodium ions without causing an increase in excretion of potassium ions.
References Gupta, et al.: J. Pharmacol. Exp. Ther., 248(3), 991 (1989)

Formula: C₁₁H₁₈ClN₇O

Color and Shape: Neat

Molecular weight: 299.76

Ref: TR-E921500

3-AMINO-N-(AMINOIMINOMETHYL)-6-CHLORO-5-[ETHYL(1-METHYLETHYL)AMINO]-2-PYRAZINECARBOXAMIDE

CAS: 1154-25-2

Formula: C₁₁H₁₈ClN₇O

Purity: 95%

Molecular weight: 299.76

Ref: 10-F386322

5-(N-Ethyl-N-isopropyl) amiloride

CAS: 1154-25-2

5-(N-Ethyl-N-isopropyl) amiloride is a cyclase inhibitor that has been shown to have anti-cancer effects in solid tumours. It blocks the production of cAMP and therefore inhibits the activation of protein kinase A, which leads to neuronal death. The drug also shows potent activity against tumours that express growth factor β1 (GFβ1). In addition, 5-(N-Ethyl-N-isopropyl) amiloride has been shown to inhibit the proliferation of HL60 cells by blocking both DNA synthesis and RNA synthesis. This inhibition is caused by an increase in proton release and polymerase chain reaction (PCR) amplification of DNA.

Formula: C₁₁H₁₈ClN₇O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 299.76 g/mol

Ref: 3D-FE16546