CAS 1154757-24-0

Plazomicin

Description:

Plazomicin is a synthetic aminoglycoside antibiotic that is primarily used to treat infections caused by multidrug-resistant Gram-negative bacteria. It is characterized by its unique structure, which includes a modified aminoglycoside backbone that enhances its stability against certain bacterial enzymes that typically confer resistance to other aminoglycosides. Plazomicin exhibits a broad spectrum of activity, particularly against Enterobacteriaceae, including strains resistant to traditional aminoglycosides. Its mechanism of action involves binding to the bacterial ribosome, inhibiting protein synthesis, and ultimately leading to cell death. The substance is administered via intravenous infusion and is primarily indicated for complicated urinary tract infections. Plazomicin's pharmacokinetics demonstrate a favorable distribution in body tissues, and it is primarily excreted unchanged in the urine. As with other aminoglycosides, monitoring for potential nephrotoxicity and ototoxicity is essential during treatment. Overall, plazomicin represents a valuable option in the antibiotic arsenal against resistant bacterial infections.

Formula: C₂₅H₄₈N₆O₁₀

InChI: InChI=1S/C25H48N6O10/c1-25(37)11-38-24(18(35)21(25)29-2)41-20-15(31-22(36)16(33)5-6-26)9-14(28)19(17(20)34)40-23-13(27)4-3-12(39-23)10-30-7-8-32/h3,13-21,23-24,29-30,32-35,37H,4-11,26-28H2,1-2H3,(H,31,36)/t13-,14+,15-,16+,17+,18-,19-,20+,21-,23-,24-,25+/m1/s1

InChI key: InChIKey=IYDYFVUFSPQPPV-PEXOCOHZSA-N

SMILES: O([C@H]1[C@H](NC([C@H](CCN)O)=O)C[C@H](N)[C@@H](O[C@H]2OC(CNCCO)=CC[C@H]2N)[C@@H]1O)[C@@H]3[C@H](O)[C@@H](NC)[C@@](C)(O)CO3

Synonyms:

• Plazomicin
• O-2-Amino-2,3,4,6-tetradeoxy-6-[(2-hydroxyethyl)amino]-α-D-glycero-hex-4-enopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)]-N1-[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-D-streptamine
• D-Streptamine, O-2-amino-2,3,4,6-tetradeoxy-6-[(2-hydroxyethyl)amino]-α-D-glycero-hex-4-enopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)]-N1-[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-
• ACHN 490
• Plazomicin API
• IYDYFVUFSPQPPV-BPUQVFSTSA-N

Plazomicin

CAS: 1154757-24-0

Plazomicin, an advanced antibiotic, resists aminoglycoside enzymes, is highly active against Enterobacteriaceae.

Formula: C₂₅H₄₈N₆O₁₀

Purity: 98%

Color and Shape: Solid

Molecular weight: 592.68

Ref: TM-T24649

Plazomicin

CAS: 1154757-24-0

Formula: C₂₅H₄₈N₆O₁₀

Molecular weight: 592.69

Ref: 4Z-P-438001