CAS 115479-40-8

4-Chloro-7-[5-O-[(1,1-dimethylethyl)dimethylsilyl]-2,3-O-(1-methylethylidene)-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Description:

4-Chloro-7-[5-O-[(1,1-dimethylethyl)dimethylsilyl]-2,3-O-(1-methylethylidene)-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-2-amine, with CAS number 115479-40-8, is a complex organic compound characterized by its unique structural features, including a pyrrolo[2,3-d]pyrimidine core and various functional groups. The presence of a chloro substituent and a silyl ether moiety indicates potential reactivity and stability under certain conditions. The β-D-ribofuranosyl group suggests that this compound may exhibit biological activity, possibly interacting with nucleic acids or enzymes. Its intricate structure, including the dimethylsilyl and isopropylidene groups, may influence its solubility, polarity, and overall pharmacokinetic properties. Such compounds are often of interest in medicinal chemistry for their potential therapeutic applications, particularly in antiviral or anticancer research. However, specific properties such as melting point, boiling point, and solubility would require empirical data for precise characterization.

Formula: C₂₀H₃₁ClN₄O₄Si

InChI: InChI=1S/C20H31ClN4O4Si/c1-19(2,3)30(6,7)26-10-12-13-14(29-20(4,5)28-13)17(27-12)25-9-8-11-15(21)23-18(22)24-16(11)25/h8-9,12-14,17H,10H2,1-7H3,(H2,22,23,24)/t12-,13-,14-,17-/m1/s1

InChI key: InChIKey=WXKYMEIKPSQDLH-VMUDFCTBSA-N

SMILES: C(O[Si](C(C)(C)C)(C)C)[C@H]1O[C@H]([C@]2([C@@]1(OC(C)(C)O2)[H])[H])N3C=4C(C=C3)=C(Cl)N=C(N)N4

Synonyms:

• 4-Chloro-7-[5-O-[(1,1-dimethylethyl)dimethylsilyl]-2,3-O-(1-methylethylidene)--D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-2-amine
• 4-Chloro-7-[5-O-[(1,1-dimethylethyl)dimethylsilyl]-2,3-O-(1-methylethylidene)-β-<span class="text-smallcaps">D</span>-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-2-amine
• 7H-Pyrrolo[2,3-d]pyrimidin-2-amine, 4-chloro-7-[5-O-[(1,1-dimethylethyl)dimethylsilyl]-2,3-O-(1-methylethylidene)-β-<span class="text-smallcaps">D</span>-ribofuranosyl]-
• Furo[3,4-d]-1,3-dioxole, 7H-pyrrolo[2,3-d]pyrimidin-2-amine deriv.
• 4-Chloro-7-[5-O-[(1,1-dimethylethyl)dimethylsilyl]-2,3-O-(1-methylethylidene)-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-2-amine
• 7H-Pyrrolo[2,3-d]pyrimidin-2-amine, 4-chloro-7-[5-O-[(1,1-dimethylethyl)dimethylsilyl]-2,3-O-(1-methylethylidene)-β-D-ribofuranosyl]-

7H-Pyrrolo[2,3-d]pyrimidin-2-amine, 4-chloro-7-[5-O-[(1,1-dimethylethyl)dimethylsilyl]-2,3-O-(1-methylethylidene)-β-D-ribofuranosyl]-

CAS: 115479-40-8

Formula: C₂₀H₃₁ClN₄O₄Si

Color and Shape: Solid

Molecular weight: 455.023

Ref: IN-DA000G1Y

9-(5''-O-t-Butyldimethylsilyl-2'',3''-O-isopropylidene-b-D-ribofuranosyl)-6-chloro-7-deazaguanine

CAS: 115479-40-8

Ref: 7W-GN6737

9-(5'-O-t-Butyldimethylsilyl-2',3'-O-isopropylidene-b-D-ribofuranosyl)-6-chloro-7-deazaguanine

CAS: 115479-40-8

9-(5'-O-t-Butyldimethylsilyl-2',3'-O-isopropylidene-b-D-ribofuranosyl)-6-chloro-7-deazaguanine is a novel nucleoside phosphoramidite. It is an analogue of the nucleoside 7-(4,4'-dimethoxytrityl)guanine and 9-(4,4'-dimethoxytrityl)guanine. This product has been shown to have anticancer activity and antiviral activity against HIV in vitro. 9-(5'-O-t-Butyldimethylsilyl-2',3'-O-isopropylidene b -D ribofuranosyl)-6 chloro -7 deazaguanine has also been shown to inhibit DNA synthesis in cells. The purity of this product is over 98%. It is a novel compound that

Formula: C₂₀H₃₃ClN₄O₄Si

Purity: Min. 95%

Molecular weight: 457.04 g/mol

Ref: 3D-NB10265