CAS 115499-13-3

vasotocin, desGly(NH2)(9)d(CH2)5-Tyr(Me)(2)-Thr(4)-Orn(8)-

Description:

Vasotocin, a peptide hormone, is characterized by its role in regulating various physiological processes, including water retention and blood pressure. The specific variant you mentioned, desGly(NH2)(9)d(CH2)5-Tyr(Me)(2)-Thr(4)-Orn(8)-, features a modified structure that includes a deletion of the glycine residue at position 9 and a substitution of a 5-carbon alkyl chain linked to a tyrosine residue with a methyl group at position 2. This modification can influence the peptide's biological activity and receptor binding affinity. Vasotocin is structurally similar to vasopressin and oxytocin, sharing a common cyclic structure that contributes to its function in the body. The presence of specific amino acids, such as ornithine and threonine, in its sequence can affect its interaction with vasopressin receptors. Overall, vasotocin is significant in neuroendocrine signaling and has implications in both vertebrate and invertebrate physiology. Its CAS number, 115499-13-3, allows for precise identification in chemical databases and research contexts.

Formula: C₄₅H₆₉N₉O₁₂S₂

InChI: InChI=1/C45H69N9O12S2/c1-5-24(2)37(52-40(60)30(20-26-14-16-28(56)17-15-26)48-36(58)21-27-10-6-7-13-34(27)68)42(62)53-38(25(3)55)43(63)50-31(22-35(47)57)39(59)51-32(23-67)44(64)54-19-9-12-33(54)41(61)49-29(11-8-18-46)45(65)66-4/h14-17,24-25,27,29-33,37-38,55-56,67H,5-13,18-23,46H2,1-4H3,(H2,47,57)(H,48,58)(H,49,61)(H,50,63)(H,51,59)(H,52,60)(H,53,62)/t24-,25+,27?,29-,30-,31-,32-,33-,37-,38-/m0/s1

Synonyms:

• beta-Mercapto-beta,beta-cyclopentamethylene-propionyl-Tyr(Me)-Ile-Thr-Asn-Cys-Pro-Orn-OH, (Disulfide bond)
• methyl N-[(2-thioxocyclohexyl)acetyl]-L-tyrosyl-L-isoleucyl-L-threonyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-ornithinate

(d(CH₂)₅¹,Tyr(Me)²,Thr⁴,Orn⁸,des-Gly-NH₂⁹)-Vasotocin

CAS: 115499-13-3

OTA (dOVT), a potent and selective in vivo oxytocin antagonist.

Formula: C₄₅H₆₉N₉O₁₂S₂

Purity: 95.8%

Color and Shape: White Lyophilisate

Molecular weight: 992.23

Ref: 01-4031339

(d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin

CAS: 115499-13-3

'(d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin blocks oxytocin receptors, stopping oxytocin effects on CA1 neuron currents.'

Formula: C₄₅H₆₉N₉O₁₂S₂

Color and Shape: Solid

Molecular weight: 992.21

Ref: TM-T76590

(d(CH2)51,Tyr(Me)2,Thr4, Orn 8,des-Gly-NH29)-Vasotocin trifluoroacetate salt

CAS: 115499-13-3

Vasotocin is a neuropeptide that regulates the release of vasopressin from the posterior pituitary gland. It is synthesized in the hypothalamus and transported to the posterior pituitary gland, where it is stored. Vasotocin has been shown to regulate blood pressure, electrolyte balance, and water balance in rats. Vasotocin also has a role in sexual behavior and reproduction. Vasotocin is an analog of vasopressin that has been modified at position 2 with an alanine residue. This modification prevents binding of vasotocin to vasopressin receptors on neurons. The sequence of this analog differs from vasopressin at positions 3, 4, 8, and 29.

Formula: C₄₅H₆₉N₉O₁₂S₂

Purity: Min. 95%

Molecular weight: 992.21 g/mol

Ref: 3D-FT108799