CAS 1156-99-6: 10-hydroxynortriptyline

Description: 10-Hydroxynortriptyline is a chemical compound that belongs to the class of tricyclic antidepressants. It is a derivative of nortriptyline, which is itself a metabolite of amitriptyline. The compound is characterized by the presence of a hydroxyl group at the 10-position of the nortriptyline structure, which influences its pharmacological properties. 10-Hydroxynortriptyline exhibits affinity for various neurotransmitter receptors, particularly those involved in the regulation of mood, such as serotonin and norepinephrine reuptake inhibitors. This compound is primarily studied for its potential therapeutic effects in treating depression and other mood disorders. Its chemical structure contributes to its lipophilicity, allowing it to cross the blood-brain barrier effectively. Additionally, the compound may exhibit varying degrees of side effects typical of tricyclic antidepressants, including sedation and anticholinergic effects. Research into its efficacy and safety profile continues, as understanding its characteristics can lead to improved treatment options for patients with mood disorders.

Formula: C₂₃H₂₅NO₅

InChI: InChI=1/C19H21NO.C4H4O4/c1-20-12-6-11-16-15-8-3-2-7-14(15)13-19(21)18-10-5-4-9-17(16)18;5-3(6)1-2-4(7)8/h2-5,7-11,19-21H,6,12-13H2,1H3;1-2H,(H,5,6)(H,7,8)/b16-11+;2-1-

Synonyms:

• 10,11-Dihydro-5-(3-(methylamino)propylidene)-5H-dibenzo(a,d)cyclohepten-10-ol
• 5H-Dibenzo(a,d)cyclohepten-10-ol, 10,11-Dihydro-5-(3-(methylamino)propylidene)-
• (5Z)-5-[3-(methylamino)propylidene]-10,11-dihydro-5H-dibenzo[a,d][7]annulen-10-ol
• (5E)-5-[3-(methylamino)propylidene]-10,11-dihydro-5H-dibenzo[a,d][7]annulen-10-ol (2Z)-but-2-enedioate (salt)
• 10-Hydroxynortriptyline

10-Hydroxy Nortriptyline (Mixture of cis and trans Isomers)

CAS: 1156-99-6

• Formula: C₁₉H₂₁NO
• Color and Shape: Off-White Solid
• Molecular weight: 279.38

10-Hydroxy Nortriptyline-13C-d3 (Mixture of Cis and Trans Isomers)

CAS: 1156-99-6

• Formula: C₂₅₁₃CH₂₄D₃NO
• Molecular weight: 373.52