CAS 1157-60-4

5-(5-O-Phosphono-β-D-ribofuranosyl)-2,4(1H,3H)-pyrimidinedione

Description:

5-(5-O-Phosphono-β-D-ribofuranosyl)-2,4(1H,3H)-pyrimidinedione, commonly known as a nucleotide analog, is characterized by its structural components that include a ribofuranosyl sugar moiety and a pyrimidinedione base. This compound features a phosphonate group, which enhances its solubility in aqueous solutions and contributes to its biological activity. The presence of the ribofuranosyl sugar indicates that it is a nucleoside derivative, which is crucial for its role in biochemical processes, particularly in nucleic acid metabolism. The pyrimidinedione structure is significant for its potential interactions with nucleic acids and enzymes, making it of interest in medicinal chemistry and biochemistry. This compound may exhibit properties such as antiviral or anticancer activity, depending on its mechanism of action and the specific biological targets it interacts with. Its CAS number, 1157-60-4, allows for easy identification in chemical databases and literature. Overall, this substance is notable for its potential applications in therapeutic contexts, particularly in the development of antiviral agents.

Formula: C₉H₁₃N₂O₉P

InChI: InChI=1S/C9H13N2O9P/c12-5-4(2-19-21(16,17)18)20-7(6(5)13)3-1-10-9(15)11-8(3)14/h1,4-7,12-13H,2H2,(H2,16,17,18)(H2,10,11,14,15)/t4-,5-,6-,7+/m1/s1

InChI key: InChIKey=MOBMOJGXNHLLIR-GBNDHIKLSA-N

SMILES: O[C@H]1[C@@H](O[C@H](COP(=O)(O)O)[C@H]1O)C=2C(=O)NC(=O)NC2

Synonyms:

• (1S)-1,4-anhydro-1-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-5-O-phosphono-D-ribitol
• 1,4-anhydro-1-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-5-O-phosphonopentitol
• 2,4(1H,3H)-Pyrimidinedione, 5-(5-O-phosphono-β-<span class="text-smallcaps">D</span>-ribofuranosyl)-
• 5-(5-O-Phosphono-β-<span class="text-smallcaps">D</span>-ribofuranosyl)-2,4(1H,3H)-pyrimidinedione
• Pseudouridine 5'-phosphate
• Pseudouridine monophosphate
• Pseudouridylic Acid
• Uracil, 5-β-<span class="text-smallcaps">D</span>-ribofuranosyl-, 5′-(dihydrogen phosphate)
• Uracil, 5-β-<span class="text-smallcaps">D</span>-ribofuranosyl-, 5′-phosphate
• Uracil, 5-β-D-ribofuranosyl-, 5′-(dihydrogen phosphate)
• Uracil, 5-β-D-ribofuranosyl-, 5′-phosphate
• 5-(5-O-Phosphono-β-D-ribofuranosyl)-2,4(1H,3H)-pyrimidinedione

Pseudouridine 5'-monophosphate disodium

CAS: 1157-60-4

Pseudouridine monophosphate disodium is an intermediate in the synthesis of uridylate, a nucleotide that is important for RNA and DNA synthesis. It is synthesized by the enzyme synthetase, which uses ATP as a phosphate donor. The enzyme has been found in rat liver microsomes and cell nuclei. Pseudouridine 5'-monophosphate disodium has an activity index of 2-3 and can be used to prepare samples for analysis by spectroscopy or chromatography. In addition, it has been shown to have biological properties such as anti-inflammatory activities and disease activity against inflammatory bowel diseases (IBD).

Formula: C₉H₁₃N₂O₉P•Na₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 370.18 g/mol

Ref: 3D-NP158356