CAS 1158560-99-6

2-chloro-N-[4-(1-cyanocyclopentyl)phenyl]-3-Pyridinecarboxamide

Description:

2-Chloro-N-[4-(1-cyanocyclopentyl)phenyl]-3-pyridinecarboxamide is a chemical compound characterized by its complex structure, which includes a pyridine ring, a chloro substituent, and a phenyl group with a cyanocyclopentyl moiety. This compound features a pyridinecarboxamide functional group, indicating the presence of both amide and carboxylic acid derivatives, which contribute to its potential biological activity. The chloro group enhances its reactivity and may influence its pharmacological properties. The presence of the cyanocyclopentyl group suggests potential applications in medicinal chemistry, particularly in the development of pharmaceuticals targeting specific biological pathways. The compound's unique structure may allow for interactions with various biological targets, making it of interest in drug discovery. Additionally, its solubility, stability, and reactivity can be influenced by the functional groups present, which are critical for its application in various chemical and biological contexts. Overall, this compound exemplifies the intricate relationship between molecular structure and biological activity in the field of chemistry.

3-PyridinecarboxaMide, 2-chloro-N-[4-(1-cyanocyclopentyl)phenyl]

CAS: 1158560-99-6

Formula: C₁₈H₁₆ClN₃O

Purity: 97%

Color and Shape: Solid

Molecular weight: 325.7921

Ref: IN-DA008U0G

2-Chloro-N-(4-(1-cyanocyclopentyl)phenyl)nicotinamide

CAS: 1158560-99-6

2-Chloro-N-(4-(1-cyanocyclopentyl)phenyl)nicotinamide

Purity: 97%

Molecular weight: 325.8g/mol

Ref: 54-OR1056893

2-Chloro-N-[4-(1-cyanocyclopentyl)phenyl]-3-pyridinecarboxamide-d8

Controlled Product

CAS: 1158560-99-6

Applications 2-Chloro-N-[4-(1-cyanocyclopentyl)phenyl]-3-pyridinecarboxamide-d8 is an intermediate used in the synthesis of Apatinib-d8 Hydrochloride (A726152), which is a labelled Apatinib (A726150). Apatinib is an orally available, small molecule multitargeted tyrosine kinase inhibitor. Apatinib selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2). Apatinib functions by inhibiting VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. Recent studies have shown that Apatinib enhances the efficacy of conventional chemotherapeutical drugs in side population (SP) cells and ABCB1-overexpressing leukemia cells.
References Mi, Y. et al.: Cancer Res., 70, 7981 (2010); Tong, X.Z. et al.: Biochem. Pharmacol., 83, 586 (2012); Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);

Formula: C₁₈D₈H₈ClN₃O

Color and Shape: Neat

Molecular weight: 333.841

Ref: TR-C364966

2-Chloro-N-[4-(1-cyanocyclopentyl)phenyl]-3-pyridinecarboxamide

Controlled Product

CAS: 1158560-99-6

Applications 2-Chloro-N-[4-(1-cyanocyclopentyl)phenyl]-3-pyridinecarboxamide is an intermediate Apatinib 25-N-Oxide (A726160), a metabolite of the antiangiogenic agent and selective VEGFR2 inhibitor Apatinib (A726150).

Formula: C₁₈H₁₆ClN₃O

Color and Shape: Neat

Molecular weight: 325.79

Ref: TR-C364965