CAS 1158728-80-3

4'-C-azido-2'-deoxy-2'-fluoro-uridine

Description:

4'-C-azido-2'-deoxy-2'-fluoro-uridine is a modified nucleoside analog that exhibits unique structural and chemical characteristics. It features an azido group (-N3) at the 4' position and a fluorine atom at the 2' position of the ribose sugar, which distinguishes it from natural nucleosides. This compound is primarily of interest in the field of medicinal chemistry and virology, particularly for its potential antiviral properties. The presence of the azido group can enhance its reactivity and facilitate incorporation into nucleic acids, while the fluorine substitution may influence its metabolic stability and binding affinity to viral enzymes. Additionally, the compound's structural modifications can affect its ability to mimic natural nucleotides, making it a valuable tool in research related to nucleic acid synthesis and antiviral drug development. As with many nucleoside analogs, its biological activity and therapeutic potential are subjects of ongoing investigation, particularly in the context of treating viral infections and possibly other diseases.

Formula: C₉H₁₀FN₅O₅

Synonyms:

• 1-[(2R,3R,4R,5R)-5-azido-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
• 4'-C-azido-2'-deoxy-2'-fluoro-uridine

4'-C-Azido-2'-deoxy-2'-fluoro-uridine

CAS: 1158728-80-3

4'-C-Azido-2'-deoxy-2'-fluoro-uridine is a novel nucleoside with antiviral and anticancer properties. 4'-C-Azido-2'-deoxy-2'-fluoro-uridine is activated by ribonucleoside kinase, which phosphorylates the 4'-C position on the sugar moiety to form the monophosphate. This drug has been shown to inhibit proliferation of human lymphoid leukemia cells in culture and to inhibit replication of HIV in cell culture. 4'-C-Azido-2'-deoxy-2'-fluoro-uridine also inhibits herpes simplex virus type 1 (HSV1) replication in vitro.

Formula: C₉H₁₀FN₅O₅

Purity: Min. 95%

Molecular weight: 287.2 g/mol

Ref: 3D-FA171138