CAS 1158838-43-7

4-[[2-[[4-[2-(4-Acetyl-1-piperazinyl)-2-oxoethyl]phenyl]amino]-5-fluoro-4-pyrimidinyl]amino]-N-(2-chlorophenyl)benzamide

Description:

The chemical substance known as 4-[[2-[[4-[2-(4-Acetyl-1-piperazinyl)-2-oxoethyl]phenyl]amino]-5-fluoro-4-pyrimidinyl]amino]-N-(2-chlorophenyl)benzamide, with the CAS number 1158838-43-7, is a complex organic compound characterized by its multi-functional structure. It features a benzamide core, which is substituted with various functional groups, including a piperazine moiety and a fluorinated pyrimidine ring. This compound is likely to exhibit significant biological activity, potentially serving as a pharmaceutical agent, given its intricate arrangement of aromatic and heterocyclic components. The presence of the acetyl group suggests potential for interactions with biological targets, while the fluorine atom may enhance lipophilicity and metabolic stability. Additionally, the chlorophenyl substitution could influence its binding affinity and selectivity towards specific receptors or enzymes. Overall, this compound's unique structural features may contribute to its efficacy in medicinal chemistry, particularly in the development of targeted therapies. However, detailed studies would be necessary to elucidate its specific properties and biological effects.

Formula: C₃₁H₂₉ClFN₇O₃

InChI: InChI=1S/C31H29ClFN7O3/c1-20(41)39-14-16-40(17-15-39)28(42)18-21-6-10-24(11-7-21)36-31-34-19-26(33)29(38-31)35-23-12-8-22(9-13-23)30(43)37-27-5-3-2-4-25(27)32/h2-13,19H,14-18H2,1H3,(H,37,43)(H2,34,35,36,38)

InChI key: InChIKey=GAAHSFKFIMENOG-UHFFFAOYSA-N

SMILES: N(C1=NC(NC2=CC=C(CC(=O)N3CCN(C(C)=O)CC3)C=C2)=NC=C1F)C4=CC=C(C(NC5=C(Cl)C=CC=C5)=O)C=C4

Synonyms:

• Benzamide, 4-[[2-[[4-[2-(4-acetyl-1-piperazinyl)-2-oxoethyl]phenyl]amino]-5-fluoro-4-pyrimidinyl]amino]-N-(2-chlorophenyl)-
• 4-[[2-[[4-[2-(4-Acetyl-1-piperazinyl)-2-oxoethyl]phenyl]amino]-5-fluoro-4-pyrimidinyl]amino]-N-(2-chlorophenyl)benzamide

Aurora A inhibitor II

CAS: 1158838-43-7

Aurora A inhibitor II is a drug that inhibits the activity of Aurora A. It has been shown to inhibit tumor growth in cancer models, as well as to prevent the formation of new blood vessels (angiogenesis). Aurora A inhibitor II is being developed for the treatment of cancers, including colon carcinoma and melanoma. The drug has also been shown to inhibit bile acid transport, which may be responsible for its antitumor activity. This drug binds to regulatory proteins and growth factors, blocking their interactions with target molecules, which leads to inhibition of cell growth and proliferation. Aurora A inhibitor II has also been shown to bind to human colon carcinomas in vitro and in vivo.

Formula: C₃₁H₂₉ClFN₇O₃

Purity: Min. 95%

Molecular weight: 602.1 g/mol

Ref: 3D-IWB83843