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CAS 115899-39-3

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5-(3-Amino-1-propyn-1-yl)-2′-deoxycytidine 5′-(tetrahydrogen triphosphate)

Description:
5-(3-Amino-1-propyn-1-yl)-2′-deoxycytidine 5′-(tetrahydrogen triphosphate), commonly referred to as a modified nucleotide, is characterized by its structural modifications that enhance its biochemical properties. This compound features a deoxycytidine backbone, which is a nucleoside component of DNA, with an amino-propynyl group at the 5-position, providing unique reactivity and potential for incorporation into nucleic acids. The presence of the triphosphate group is crucial for its role in biochemical processes, as it serves as a substrate for polymerases during DNA synthesis. The modification allows for increased stability and resistance to nucleases, making it a valuable tool in molecular biology and genetic engineering applications. Additionally, its unique structure may influence its interaction with enzymes and other biomolecules, potentially leading to novel therapeutic applications. Overall, this compound exemplifies the intersection of chemistry and biology, showcasing how structural modifications can enhance the functionality of nucleotides in various scientific fields.
Formula:C12H19N4O13P3
InChI:InChI=1S/C12H19N4O13P3/c13-3-1-2-7-5-16(12(18)15-11(7)14)10-4-8(17)9(27-10)6-26-31(22,23)29-32(24,25)28-30(19,20)21/h5,8-10,17H,3-4,6,13H2,(H,22,23)(H,24,25)(H2,14,15,18)(H2,19,20,21)/t8-,9+,10+/m0/s1
InChI key:InChIKey=LVTQIVFSMGDIPF-IVZWLZJFSA-N
SMILES:O=C1N(C=C(C#CCN)C(N)=N1)[C@@H]2O[C@H](COP(OP(OP(=O)(O)O)(=O)O)(=O)O)[C@@H](O)C2
Synonyms:
  • Cytidine 5′-(tetrahydrogen triphosphate), 5-(3-amino-1-propyn-1-yl)-2′-deoxy-
  • 2: PN: WO2012150035 PAGE: 45 claimed sequence
  • 5-(3-Amino-1-propyn-1-yl)-2′-deoxycytidine 5′-(tetrahydrogen triphosphate)
  • Cytidine 5′-(tetrahydrogen triphosphate), 5-(3-amino-1-propynyl)-2′-deoxy-
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