CAS 1159174-26-1

[7-(TRIMETHYLAMMONIUM)HEPYL] METHANETHIOSULFONATE BROMIDE

Description:

[7-(Trimethylammonium)heptyl] methanethiosulfonate bromide is a quaternary ammonium compound characterized by its cationic nature due to the presence of a trimethylammonium group. This compound features a heptyl chain, which contributes to its hydrophobic properties, while the methanethiosulfonate moiety provides a reactive thiol group that can participate in various chemical reactions, including disulfide bond formation. The bromide ion serves as a counterion, enhancing the solubility of the compound in polar solvents. Typically, such compounds exhibit surfactant properties, making them useful in biological and chemical applications, including as cell membrane permeabilizers or in the synthesis of functionalized surfaces. The presence of both hydrophilic and hydrophobic regions allows for amphiphilic behavior, which can facilitate interactions with biological membranes. Additionally, the compound may exhibit antimicrobial properties due to its cationic nature, making it of interest in pharmaceutical and biotechnological research. Safety and handling precautions should be observed, as with many quaternary ammonium compounds, due to potential toxicity and environmental impact.

Formula: C₁₁H₂₆BrNO₂S₂

Synonyms:

• MTSHepT
• N,N,N-TriMethyl-7-[(Methylsulfonyl)thio]-1-heptanaMiniuM BroMide
• [7-(TRIMETHYLAMMONIUM)HEPYL] METHANETHIOSULFONATE BROMIDE

[7-(Trimethylammonium)hepyl] Methanethiosulfonate Bromide

Controlled Product

CAS: 1159174-26-1

Stability Moisture Sensitive
Applications Reacts specifically and rapidly with thiols to form mixed disulfides. Used to probe the structures of the ACh receptor channel of the GABAA receptor channel and of lactose permease.
References Duhten, R.L., et al.: Biochemistry, 32, 3139 (1993), Yang, N. et al.: Neuron, 16, 113 (1996), Kuner, T. et al.: Neuron, 17, 343 (1996), Holmgren, M. et al: Neuropharmacology, 35, 797 (1996), Chahine, M. et al.: Biochemical & Biophysical Res. Commun., 233, 606 (1997), Ehrlich, B.E., et al.: J. Gen. Physiol., 109, 255 (1997), Rassendren, F., et al.: The EMBO Journal, 16, 3446 (1997), Vedantham, V. and Cannon, C.C.: J. Gen. Physiol., 111, 83 (1998), Lin, C.-W. and Tsung-Yu, C.: J. Gen. Physiol., 116, 535 (2000), Sullivan, D.A. and Cohen, J.B.: J. B.C., 275, 17, 12651 (2000)

Formula: C₁₁H₂₆NO₂S₂·Br

Color and Shape: Neat

Molecular weight: 348.36

Ref: TR-T795906