CAS 1159588-21-2

(Z)-Pitavastatin Calcium Salt

Description:

(Z)-Pitavastatin Calcium Salt is a synthetic compound belonging to the statin class of drugs, primarily used for lowering cholesterol levels in the blood. It functions as an HMG-CoA reductase inhibitor, which plays a crucial role in cholesterol biosynthesis. The compound is characterized by its specific stereochemistry, indicated by the (Z) configuration, which refers to the arrangement of substituents around a double bond. This stereochemical configuration is essential for its biological activity. Pitavastatin is known for its potency and selectivity, making it effective in reducing low-density lipoprotein (LDL) cholesterol while having a favorable effect on high-density lipoprotein (HDL) cholesterol levels. The calcium salt form enhances its solubility and stability, facilitating its formulation into oral dosage forms. Additionally, (Z)-Pitavastatin exhibits a relatively long half-life, allowing for once-daily dosing. As with other statins, it may have side effects, including muscle pain and liver enzyme elevation, necessitating monitoring during therapy. Overall, (Z)-Pitavastatin Calcium Salt is a valuable therapeutic agent in managing dyslipidemia and reducing cardiovascular risk.

Formula: C₂₅H₂₃FNO₄

Synonyms:

• 7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic Acid
• (3R,5S,6Z)-Pitavastatin Calcium
• Pitavastatin impurity 6/(Z)-Pitavastatin Calcium Salt
• Pitavastatin Z- isomer
• Pitavastatin Impurity 5(Pitavastatin Calcium (Z)-Isomer)
• (Z,3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoate
• (Z)-Pitavastatin Calcium Salt
• Pitavastatin Calcium (Z)-Isomer
• (Z)-Pitavastatin calcium

(Z)-Pitavastatin Calcium Salt

CAS: 1159588-21-2

Formula: C₅₀H₄₆CaF₂N₂O₈

Purity: 95%

Color and Shape: Solid

Molecular weight: 880.9836

Ref: IN-DA008WOO

Calcium (3R,5S,Z)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoate

CAS: 1159588-21-2

Calcium (3R,5S,Z)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoate

Purity: 95%

Molecular weight: 881g/mol

Ref: 54-IN13070

(Z)-Pitavastatin Calcium Salt

CAS: 1159588-21-2

Formula: C₂₅H₂₃FNO₄·Ca

Color and Shape: White To Off-White Solid

Molecular weight: 2*420.46 40.08

Ref: 4Z-P-6424

Pitavastatin Calcium (Z)-Isomer

CAS: 1159588-21-2

Formula: C₂₅H₂₃FNO₄(ca)

Molecular weight: 420.46 : 1/2(40.08)

Ref: ST-EA-CP-P23002

(Z)-Pitavastatin Calcium Salt

Controlled Product

CAS: 1159588-21-2

Applications (Z)-Pitavastatin is the Z-isomer of Pitavastatin (P531000), a competitive inhibitor of HMG-CoA reductase and a antilipemic agent.
References Aoki, T., et al.: Arzneim.-Forsch., 47, 904 (1997), Yamada, I., et al.: Xenobiotica, 33, 789 (2003), Park, S., et al.: Clin. Ther., 27, 1074 (2005),

Formula: C₂₅H₂₃FNO₄·Ca

Color and Shape: Neat

Molecular weight: 880.984

Ref: TR-P531040

Pitavastatin Z-isomer impurity

CAS: 1159588-21-2

The Z-isomer impurity of pitavastatin is a synthetic compound that has been used as an analytical standard and pharmacopoeia reference. The Z-isomer impurity is not found in nature, but is generated by the hydrogenation of the natural product. It has been shown to be metabolized by CYP3A4 and CYP2C9 enzymes, which are the primary enzymes responsible for drug metabolism. This impurity does not have any therapeutic effect on the body, but can be used as a research and development standard for HPLC.

Purity: Min. 95%

Ref: 3D-IP145423

(Z)-Pitavastatin calcium

CAS: 1159588-21-2

(Z)-Pitavastatin calcium is the Z-Isomer of Pitavastatin hemicacium. Pitavastatin calcium is a potent of hydroxymethylglutaryl-CoA (HMG-CoA) reductase.

Formula: C₅₀H₅₀CaF₂N₂O₈

Purity: 98%

Color and Shape: Solid

Molecular weight: 885.031

Ref: TM-T13380