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CAS 116-38-1

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Edrophonium chloride

Description:
Edrophonium chloride is a quaternary ammonium compound primarily known for its role as a reversible inhibitor of the enzyme acetylcholinesterase. This inhibition leads to an increase in acetylcholine levels at neuromuscular junctions, making it useful in the diagnosis of myasthenia gravis and for certain types of muscle weakness. The substance appears as a white crystalline powder and is soluble in water, which facilitates its administration via injection. Its mechanism of action involves binding to the active site of acetylcholinesterase, thereby preventing the breakdown of acetylcholine, resulting in prolonged neuromuscular transmission. Edrophonium chloride has a relatively short duration of action, typically lasting only a few minutes to an hour, which is beneficial for diagnostic purposes. Additionally, it may cause side effects such as muscle twitching, bradycardia, and gastrointestinal disturbances due to its cholinergic activity. As with any medication, its use should be carefully monitored, particularly in patients with underlying health conditions.
Formula:C10H16NO·Cl
InChI:InChI=1S/C10H15NO.ClH/c1-4-11(2,3)9-6-5-7-10(12)8-9;/h5-8H,4H2,1-3H3;1H
InChI key:InChIKey=BXKDSDJJOVIHMX-UHFFFAOYSA-N
SMILES:[N+](CC)(C)(C)C1=CC(O)=CC=C1.[Cl-]
Synonyms:
  • Ammonium, ethyl(m-hydroxyphenyl)dimethyl-, chloride
  • Antirex
  • Benzenaminium, N-ethyl-3-hydroxy-N,N-dimethyl-, chloride
  • Benzenaminium, N-ethyl-3-hydroxy-N,N-dimethyl-, chloride (1:1)
  • Chlorure D'Edrophonium
  • Cloruro De Edrofonio
  • Dimethylethyl (m-hydroxyphenyl) ammonium chloride
  • Dimethylethyl(3-hydroxyphenyl)ammonium chloride
  • Edrophone chloride
  • Edrophoniumchlorid
  • See more synonyms
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