CAS 116-43-8: Succinylsulfathiazole
Description:Succinylsulfathiazole is a sulfonamide antibiotic that is primarily used for its antibacterial properties. It is characterized by its sulfonamide group, which is essential for its antimicrobial activity, and a thiazole ring that contributes to its chemical stability and solubility. The compound is typically a white to off-white crystalline powder, and it is soluble in water, which facilitates its use in various formulations. Succinylsulfathiazole works by inhibiting bacterial growth through the competitive inhibition of the enzyme dihydropteroate synthase, which is involved in folate synthesis. This mechanism makes it effective against a range of Gram-positive and Gram-negative bacteria. Additionally, it has been used in the treatment of gastrointestinal infections due to its localized action in the intestines. However, its use has declined with the advent of more effective antibiotics and concerns regarding resistance. As with many sulfonamides, potential side effects may include allergic reactions and hematological issues, necessitating careful monitoring during treatment.
Formula:C13H13N3O5S2
InChI:InChI=1S/C13H13N3O5S2/c17-11(5-6-12(18)19)15-9-1-3-10(4-2-9)23(20,21)16-13-14-7-8-22-13/h1-4,7-8H,5-6H2,(H,14,16)(H,15,17)(H,18,19)
InChI key:InChIKey=SKVLYVHULOWXTD-UHFFFAOYSA-N
SMILES:O=C(O)CCC(=O)NC1=CC=C(C=C1)S(=O)(=O)NC2=NC=CS2
- Synonyms:
- 2-(N<sup>4</sup>-Succinylsulfanilamido)thiazole
- 3-([4-[(1,3-Thiazol-2-yl)sulfamoyl]phenyl]carbamoyl)propanoic acid
- 4-Oxo-4-[[4-[(2-thiazolylamino)sulfonyl]phenyl]amino]butanoic acid
- 4-Oxo-4-{[4-(1,3-Thiazol-2-Ylsulfamoyl)Phenyl]Amino}Butanoic Acid
- 4′-(2-Thiazolylsulfamoyl)succinanilic acid
- Butanoic acid, 4-oxo-4-[[4-[(2-thiazolylamino)sulfonyl]phenyl]amino]-
- Colistatin
- Cremosuxidine
- Kaoxidin
- Kaoxidine
- See more synonyms
- NSC 14193
- NSC 163939
- Rolsul
- SST
- Succinanilic acid, 4′-(2-thiazolylsulfamoyl)-
- Succinylsulphathiazole
- Sulfadigesin
- Sulfasuccidin
- Sulfasuccidine
- Sulfasuccinil
- Sulfasuccithiazole
- Sulfasuxidine
- Sulfenterone
- Thiacyl
- p-2-Thiazolylsulfamylsuccinanilic acid