CAS 116-43-8

Succinylsulfathiazole

Description:

Succinylsulfathiazole is a sulfonamide antibiotic that is primarily used for its antibacterial properties. It is characterized by its sulfonamide group, which is essential for its antimicrobial activity, and a thiazole ring that contributes to its chemical stability and solubility. The compound is typically a white to off-white crystalline powder, and it is soluble in water, which facilitates its use in various formulations. Succinylsulfathiazole works by inhibiting bacterial growth through the competitive inhibition of the enzyme dihydropteroate synthase, which is involved in folate synthesis. This mechanism makes it effective against a range of Gram-positive and Gram-negative bacteria. Additionally, it has been used in the treatment of gastrointestinal infections due to its localized action in the intestines. However, its use has declined with the advent of more effective antibiotics and concerns regarding resistance. As with many sulfonamides, potential side effects may include allergic reactions and hematological issues, necessitating careful monitoring during treatment.

Formula: C₁₃H₁₃N₃O₅S₂

InChI: InChI=1S/C13H13N3O5S2/c17-11(5-6-12(18)19)15-9-1-3-10(4-2-9)23(20,21)16-13-14-7-8-22-13/h1-4,7-8H,5-6H2,(H,14,16)(H,15,17)(H,18,19)

InChI key: InChIKey=SKVLYVHULOWXTD-UHFFFAOYSA-N

SMILES: S(NC1=NC=CS1)(=O)(=O)C2=CC=C(NC(CCC(O)=O)=O)C=C2

Synonyms:

• 2-(N⁴-Succinylsulfanilamido)thiazole
• 3-([4-[(1,3-Thiazol-2-yl)sulfamoyl]phenyl]carbamoyl)propanoic acid
• 4-Oxo-4-[[4-[(2-thiazolylamino)sulfonyl]phenyl]amino]butanoic acid
• 4-Oxo-4-{[4-(1,3-Thiazol-2-Ylsulfamoyl)Phenyl]Amino}Butanoic Acid
• 4′-(2-Thiazolylsulfamoyl)succinanilic acid
• Butanoic acid, 4-oxo-4-[[4-[(2-thiazolylamino)sulfonyl]phenyl]amino]-
• Colistatin
• Cremosuxidine
• Kaoxidin
• Kaoxidine
• NSC 14193
• NSC 163939
• Rolsul
• SST
• Succinanilic acid, 4′-(2-thiazolylsulfamoyl)-
• Succinylsulphathiazole
• Sulfadigesin
• Sulfasuccidin
• Sulfasuccidine
• Sulfasuccinil
• Sulfasuccithiazole
• Sulfasuxidine
• Sulfenterone
• Thiacyl

Butanoic acid, 4-oxo-4-[[4-[(2-thiazolylamino)sulfonyl]phenyl]amino]-

CAS: 116-43-8

Formula: C₁₃H₁₃N₃O₅S₂

Purity: %

Color and Shape: Solid

Molecular weight: 355.3894

Ref: IN-DA000BCQ

Succinylsulfathiazole

CAS: 116-43-8

Succinylsulfathiazole (Succinylsulphathiazole) is a sulfonamide. An ultra long-acting drug.

Formula: C₁₃H₁₃N₃O₅S₂

Purity: 98.77%

Color and Shape: Solid

Molecular weight: 355.39

Ref: TM-T0749

Succinylsulfathiazole

CAS: 116-43-8

Succinylsulfathiazole

Purity: 98%

Molecular weight: 355.39g/mol

Ref: 54-OR1015091

Succinylsulfathiazole

CAS: 116-43-8

Succinylsulfathiazole

Purity: ≥98%

Molecular weight: 355.39g/mol

Ref: 54-BUP17048

Succinylsulfathiazole

CAS: 116-43-8

Formula: C₁₃H₁₃N₃O₅S₂·xH₂O

Purity: 99.0 - 101.0 % (dried basis)

Color and Shape: White or yellowish-white crystalline powder

Molecular weight: 355.39 (anhydrous)

Ref: 7W-GA4716

Succinylsulfathiazole

CAS: 116-43-8

Formula: C₁₃H₁₃N₃O₅S₂

Color and Shape: Neat

Molecular weight: 355.39

Ref: 04-C16985600

Succinylsulfathiazole

Controlled Product

CAS: 116-43-8

Applications Succinylsulfathiazole is a sulfonamide antibiotic that was shown to inhibit bacteria that are responsible for folate production. Succinylsulfathiazole was used in various folate deficiency studies to block the synthesis of folic acid.
References Semchuk, G.M., et al.: J. Nutrition., 124, 1118 (1994); Adikrisna, R., et al.: Gastroenterol., 143, 234 (2012); Suihko, E., et al.: J. Pharma. Sci., 94, 745 (2005);

Formula: C₁₃H₁₃N₃O₅S₂

Color and Shape: White To Off-White

Molecular weight: 355.39

Ref: TR-S692170

Succinylsulfathiazole

CAS: 116-43-8

Succinylsulfathiazole is a sulfa drug that has antimicrobial activity. It is a structural analogue of sulfanilamide, which is an antibiotic used to treat infectious diseases. Sulfa drugs are structurally related to the amino acid pantothenic acid and have been shown to have beneficial effects in animal models for bowel disease, autoimmune diseases, and other conditions. Succinylsulfathiazole has been shown to inhibit the growth of Aerobacter aerogenes and other bacteria by binding to their cell wall and interfering with synthesis of DNA. Succinylsulfathiazole has been shown to inhibit the growth of Aerobacter aerogenes and other bacteria by binding to their cell wall and interfering with synthesis of DNA.

Formula: C₁₃H₁₃N₃O₅S₂

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 355.39 g/mol

Ref: 3D-FS41022

Succinylsulfathiazole

CAS: 116-43-8

Formula: C₁₃H₁₃N₃O₅S₂

Purity: ≥99 %

Molecular weight: 355.38

Ref: 10-F544151