CAS 116-58-5

4-pregnene-11B,17A,20B,21-tetrol-3-one

Description:

4-Pregnene-11B,17A,20B,21-tetrol-3-one, also known as 21-hydroxyprogesterone, is a steroid hormone that plays a crucial role in the biosynthesis of other steroid hormones. It is characterized by its four-ring core structure typical of steroids, with specific hydroxyl (-OH) groups at positions 11, 17, 20, and 21, and a ketone group at position 3. This compound is primarily involved in the regulation of various physiological processes, including the menstrual cycle and pregnancy. It is produced in the adrenal glands and gonads and is a precursor to cortisol and other corticosteroids. In clinical settings, 21-hydroxyprogesterone is often measured to assess adrenal function and diagnose conditions such as congenital adrenal hyperplasia. Its CAS number, 116-58-5, is a unique identifier that facilitates the identification and study of this compound in scientific literature and databases. Overall, 4-pregnene-11B,17A,20B,21-tetrol-3-one is significant in both biochemistry and medicine.

Formula: C₂₁H₃₂O₅

InChI: InChI=1/C21H32O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-18,22,24-26H,3-8,10-11H2,1-2H3/t14-,15-,16-,17-,18+,19-,20-,21-/m0/s1

Synonyms:

• 11-Beta,17-Alpha-20-Beta,21-Tetrahydroxypregn-4-En-3-One
• (11beta,20S)-11,17,20,21-tetrahydroxypregn-4-en-3-one

20-β-Hydroxy Hydrocortisone

CAS: 116-58-5

Formula: C₂₁H₃₂O₅

Molecular weight: 364.49

Ref: 4Z-H-103007

20b-Dihydrocortisol

Controlled Product

CAS: 116-58-5

Applications 20β-Dihydrocortisol could be used as a potential non invasive diagnostic test of transmissible spongiform encephalopaties. 20β-Dihydrocortisol is a metabolite of Cortisol (H714615), a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat, protein and carbohydrate metabolism.
References Schelcher, F., et. al.: Endocrinology, 140, 2422 (1999); Phillipov, G., et. al.: J. Clin. Endocr. Metab., 81, 3855 (1996); Vigore, L., et al.: Cancer Ther., 6, 699 (2008); Puurunen, J., et al.: J. Clin. Endocrinol. Metab., 94, 1973 (2009); Lemos, D., et al.: J. Endocrinol., 201, 275 (2009); Chen, S., et al.: Am. J. Physiol., 296 (2009)

Formula: C₂₁H₃₂O₅

Color and Shape: White To Off-White

Molecular weight: 364.48

Ref: TR-D448740

20β-Dihydrocortisol

CAS: 116-58-5

Formula: C₂₁H₃₂O₅

Molecular weight: 364.48

Ref: ST-EA-CP-H9113