CAS 1160514-60-2

1H-Pyrazole-4-carboxylic acid, 1-[4-[(2,3,3-trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-, ethyl ester

CAS: 1160514-60-2

Formula: C₁₆H₁₁Cl₃F₃N₃O₃

Purity: 99%

Color and Shape: Solid

Molecular weight: 456.6310

Ref: IN-DA000BGZ

Pyr3

CAS: 1160514-60-2

Pyr3

Purity: ≥98%

Molecular weight: 456.63g/mol

Ref: 54-BUP15288

Pyr3

Controlled Product

CAS: 1160514-60-2

Applications Pyr3 is a pyrazole derivative that is used to discriminate between (transient receptor potential cation) TRPC4 mediated receptor operated calcium entry and STIM1/Ora1 mediated store operated calcium entry pathway in human embryonic kidney and rat mast cells.
References Schieifer, H., et al.: Brit. J. Pharmacol., 167, 1712 (2012); Bergsmann, J., et al.: J. Biol. Chem., 286, 31565 (2011)

Formula: C₁₆H₁₁Cl₃F₃N₃O₃

Color and Shape: Neat

Molecular weight: 456.63

Ref: TR-P840385

Pyr3

CAS: 1160514-60-2

Purity: 99%

Molecular weight: 456.63

Ref: 10-F979722

TRPC3 Channel Inhibitor, Pyr3

CAS: 1160514-60-2

Pyr3 is a TRPC3 channel inhibitor. It selectively blocks the TRPC3 channel, which is involved in regulating mitochondrial membrane potential and ion homeostasis. Pyr3 also has anti-inflammatory properties and may be useful for the treatment of hepatic steatosis or neurodegenerative diseases. The drug can reduce neuronal death by inhibiting the release of neurotransmitters such as neurokinin-1 receptor. Pyr3 also inhibits cardiac contractility, cyclase activity, and disulfide bond formation at low concentrations. This agent also has a potential use as an anti-tumor drug due to its ability to inhibit toll-like receptor signaling pathways that are important in tumor cell proliferation.

Formula: C₁₆H₁₁Cl₃F₃N₃O₃

Purity: Min. 95%

Molecular weight: 456.63 g/mol

Ref: 3D-KWB51460

Pyr3

CAS: 1160514-60-2

Pyr3 selectively blocks TRPC3 channels, reducing Ca2+ influx; it's effective at 700 nM.

Formula: C₁₆H₁₁Cl₃F₃N₃O₃

Purity: 98.04%

Color and Shape: Solid

Molecular weight: 456.63

Ref: TM-T16687