CAS 1160521-50-5

ITI-214 free base

CAS: 1160521-50-5

ITI-214: potent PDE1 inhibitor, Ki=58 pM, highly selective vs. other PDEs and enzymes/receptors.

Formula: C₂₉H₂₆FN₇O

Purity: 98%

Color and Shape: Solid

Molecular weight: 507.56

Ref: TM-T11688

ITI-214

CAS: 1160521-50-5

ITI-214 is a new drug that has been shown to have a number of potential therapeutic uses. It has been shown to inhibit locomotor activity, which may be due to its ability to inhibit the release of calcium from the sarcoplasmic reticulum. ITI-214 also inhibits cyclic nucleotide phosphodiesterases, which are enzymes that break down cyclic nucleotides and thereby regulate cellular function. This inhibition leads to an increase in intracellular levels of cAMP, leading to enhanced physiological function. ITI-214 has been shown to have anti-cancer effects in vitro and in vivo. It also enhances the efficacy of cancer treatments such as radiation therapy and chemotherapy, by inhibiting tumor growth and enhancing immune responses against cancer cells. The mechanism by which ITI-214 exerts these effects is not yet known but may be related to its ability to inhibit Ercc1, a gene associated with hereditary colon cancer susceptibility or other genes involved in DNA repair pathways.

Formula: C₂₉H₂₆FN₇O

Purity: Min. 95%

Molecular weight: 507.6 g/mol

Ref: 3D-KWB52150