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CAS 116057-75-1

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Idoxifene

Description:
Idoxifene is a synthetic compound classified as a selective estrogen receptor modulator (SERM). It is primarily studied for its potential use in the treatment of breast cancer and osteoporosis due to its ability to selectively bind to estrogen receptors, mimicking or blocking estrogen's effects in different tissues. Idoxifene exhibits a unique profile, acting as an estrogen agonist in some tissues, such as bone, while functioning as an antagonist in others, like breast tissue. This selective action helps to mitigate some of the adverse effects associated with traditional estrogen therapies. The compound is characterized by its chemical structure, which includes a phenolic group, contributing to its interaction with estrogen receptors. Idoxifene has been investigated in clinical settings, showing promise in improving bone density and reducing the risk of fractures, while also demonstrating anti-tumor activity in estrogen-dependent breast cancer models. However, like many SERMs, it may also present side effects, necessitating careful consideration in therapeutic applications.
Formula:C28H30INO
InChI:InChI=1S/C28H30INO/c1-2-27(22-8-4-3-5-9-22)28(23-10-14-25(29)15-11-23)24-12-16-26(17-13-24)31-21-20-30-18-6-7-19-30/h3-5,8-17H,2,6-7,18-21H2,1H3/b28-27-
InChI key:InChIKey=JJKOTMDDZAJTGQ-DQSJHHFOSA-N
SMILES:C(=C(/CC)\C1=CC=CC=C1)(\C2=CC=C(OCCN3CCCC3)C=C2)/C4=CC=C(I)C=C4
Synonyms:
  • (E)-1-(2-(4-(1-(4-Iodophenyl)-2-phenyl-1-butenyl)phenoxy)ethyl)pyrrolidine
  • 1-(2-(p-((E)-beta-Ethyl-alpha-(p-iodophenyl)styryl)phenoxy)ethyl)pyrrolidine
  • 1-(2-{4-[(1E)-1-(4-iodophenyl)-2-phenylbut-1-en-1-yl]phenoxy}ethyl)pyrrolidine
  • 1-[2-[4-[(1E)-1-(4-Iodophenyl)-2-phenyl-1-buten-1-yl]phenoxy]ethyl]pyrrolidine
  • Cb 7432
  • Idoxifene [USAN:INN:BAN]
  • Iodoxifene
  • Pyrrolidine, 1-(2-(4-(1-(4-iodophenyl)-2-phenyl-1-butenyl)phenoxy)ethyl-, (E)-
  • Pyrrolidine, 1-[2-[4-[(1E)-1-(4-iodophenyl)-2-phenyl-1-buten-1-yl]phenoxy]ethyl]-
  • Pyrrolidine, 1-[2-[4-[(1E)-1-(4-iodophenyl)-2-phenyl-1-butenyl]phenoxy]ethyl]-
  • See more synonyms
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