CAS 1161205-04-4

VU 0361737

Description:

VU 0361737, identified by its CAS number 1161205-04-4, is a chemical compound that has garnered interest in the field of neuroscience and pharmacology. It is primarily recognized as a selective antagonist of the metabotropic glutamate receptor subtype 2 (mGluR2), which plays a significant role in modulating neurotransmission and synaptic plasticity. The compound's structure features specific functional groups that contribute to its binding affinity and selectivity for the mGluR2 receptor. Research indicates that VU 0361737 may have potential therapeutic applications in treating various neurological disorders, including anxiety and schizophrenia, by influencing glutamatergic signaling pathways. Additionally, its pharmacokinetic properties, such as solubility and stability, are essential for determining its efficacy and safety in clinical settings. Overall, VU 0361737 represents a valuable tool for studying mGluR2-related mechanisms and developing new treatments for psychiatric conditions.

N-(4-Chloro-3-methoxyphenyl)pyridine-2-carboxamide

CAS: 1161205-04-4

Formula: C₁₃H₁₁ClN₂O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 262.6916

Ref: IN-DA000BOL

N-(4-Chloro-3-Methoxyphenyl)Picolinamide

CAS: 1161205-04-4

N-(4-Chloro-3-Methoxyphenyl)Picolinamide

Purity: 98%

Molecular weight: 262.69g/mol

Ref: 54-OR1014000

VU0361737

CAS: 1161205-04-4

VU0361737

Purity: ≥98%

Molecular weight: 262.69g/mol

Ref: 54-BUP13612

VU0361737

CAS: 1161205-04-4

VU0361737 (ML-128) is a mGlu4 PAM; EC50 is 240 nM (human) and 110 nM (rat), weak at mGlu5/8, inactive at mGlu1/2/3/6/7, CNS-penetrant.

Formula: C₁₃H₁₁ClN₂O₂

Purity: 99.60% - 99.85%

Color and Shape: Solid

Molecular weight: 262.69

Ref: TM-T6726

2-Pyridinecarboxamide, N-(4-chloro-3-methoxyphenyl)-

CAS: 1161205-04-4

Purity: 99%

Molecular weight: 262.6900024

Ref: 10-F861543

VU 0361737

CAS: 1161205-04-4

VU 0361737 is a small molecule that has been shown to have anti-inflammatory properties. It binds to glutamate receptors, which are involved in the regulation of inflammatory responses and pain. VU 0361737 also blocks microglia activation, prevents glutamate toxicity, and inhibits tumor progression in a mouse model of melanoma. It was also found to be neuroprotective against glutamate-induced neurotoxicity in primary hippocampal neurons and cerebellar granule cells. The molecular mode of action of VU 0361737 is not completely understood, but it may be due to its ability to block the adenosine receptor A2A signaling pathway.

Formula: C₁₃H₁₁ClN₂O₂

Purity: Min. 95%

Molecular weight: 262.69 g/mol

Ref: 3D-LWB20504